Distribution of brain HIV load in AIDS.

Brain Pathology
Clayton A WileyCristian L Achim

Abstract

Approximately one quarter of patients with AIDS develop severe cognitive deficits called HIV-associated dementia complex (ADC). There is some controversy regarding the importance of viral load in mediating neurologic disease. With the advent of sensitive, quantitative and reproducible RNA assays for HIV load in plasma and CSF, we quantified viral load in brains from 10 autopsied HIV-infected subjects and 2 non-infected controls. The new quantitative HIV RNA assays showed general agreement with previously used semi-quantitative immunocytochemical assessments of HIV envelope protein, and were performed without professional subjective interpretation. All cases with very high levels of HIV in the CSF, had high overall levels in the brain, suggesting that CSF viral loads exceeding 10(6) copies per mL may be a surrogate marker of high viral load in the brain. Levels of virus in the spleen showed no clear association with those found in the brain. HIV RNA was not uniformly distributed throughout the brain. Selective regions, including basal ganglia and hippocampus, showed higher levels of virus than the cerebellar cortex and mid-frontal cortical gray matter. Assessment of overall brain viral load requires careful attention to regional...Continue Reading

References

Sep 1, 1992·Annals of Neurology·E MasliahC A Wiley
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
May 1, 1994·Journal of Neuropathology and Experimental Neurology·C L AchimC A Wiley
Nov 1, 1993·Neurology·J D GlassJ C McArthur
Jun 1, 1996·Nature Medicine·M S SaagP A Volberding
Aug 1, 1996·Nature Medicine·F DianzaniG Visco

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Citations

Nov 2, 2005·Neurotoxicity Research·I P EverallE Masliah
Dec 21, 2006·Nature Reviews. Neuroscience·Ronald EllisEliezer Masliah
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph P SteinerAvindra Nath
Feb 22, 2008·Molecular Diagnosis & Therapy·Alireza MinagarPaul Shapshak
Feb 13, 2008·CNS Spectrums·M KumarC Eisdorfer
May 23, 2009·Neuropsychology Review·Steven Paul WoodsIgor Grant
Oct 1, 2013·Journal of Neurovirology·Mario OrtegaBeau M Ances
Nov 5, 2014·Journal of Neurovirology·Avindra Nath
Nov 5, 2014·Journal of Neurovirology·Jenna B HoneycuttJ Victor Garcia
Aug 11, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Man WangHong Shang
May 14, 2016·Journal of Neural Transmission·Stéfan du PlessisRobin Emsley
Oct 9, 2016·Journal of Neurovirology·C S HakkersM Vink
Oct 14, 2000·New Directions for Mental Health Services·S J Ferrando
Sep 15, 2001·Journal of Neuropathology and Experimental Neurology·J Torres-MuñozC K Petito
Dec 16, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Stewart A FactorSusan A Weaver
Nov 27, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Alessia BachisItalo Mocchetti
Jul 13, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Benjamin B GelmanChristopher J Lahart
Dec 8, 2010·Proteomics. Clinical Applications·Stephanie Kraft-TerryLoyda M Meléndez
Oct 13, 2011·Reviews in Medical Virology·María del PalacioM Ángeles Muñoz-Fernández
May 12, 2009·Neuropsychology Review·Pauline M Maki, Eileen Martin-Thormeyer
Oct 7, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Landhing M MoranCharles F Mactutus
Oct 30, 2016·The Journal of Infectious Diseases·Albert M AndersonUNKNOWN CHARTER Group
Nov 20, 2016·Journal of the Pediatric Infectious Diseases Society·C Paula Lewis-de Los AngelesUNKNOWN Pediatric HIV/AIDS Cohort Study (PHACS)
Jun 9, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·E A Nickoloff-BybelJ W Berman

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