Distribution of Ca2+-activated K+ channel (SK2 and SK3) immunoreactivity in intestinal smooth muscles of the guinea-pig

Clinical and Experimental Pharmacology & Physiology
M F Klemm, R J Lang

Abstract

1. The tissue distribution of small conductance Ca(2+)-activated K(+) channels (SK2 and SK3) was examined in three preparations of the guinea-pig intestine: the taneia caeci and the circular muscle layer of the stomach and proximal colon. 2. The SK3 immunoreactive (SK3-IR) cells were bi- or multipolar in appearance with numerous short processes, which formed an interconnecting network at the myenteric and submucous borders of the stomach and proximal colon. The SK3-IR cells were also present within the circular muscle layer of these preparations and throughout the taenia caeci. 3. Although SK3-IR cells had a similar distribution as cells immunoreactive for c-Kit (c-Kit-IR), the marker for interstitial cells of Cajal (ICC), only 5-10% of c-Kit-IR ICC were also SK3-IR. 4. The SK3-IR cells were clearly ICC when examined with the electron microscope. Close associations of SK3-IR ICC (ICC-SK3) and nerves were often observed, as were gap junctions with SK3-negative ICC and smooth muscle cells. 5. Punctate SK2 and SK3 channel immunoreactivity was present on the plasmalemmal surface of all smooth muscle cells examined. 6. We conclude that ICC-SK3 are a subpopulation of ICC that are directly innervated by enteric inhibitory motor nerves.

References

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Citations

May 4, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·T M MatthewsP A Fuchs
Jul 3, 2007·Pflügers Archiv : European journal of physiology·Yoshihiko Kito, Hikaru Suzuki
Jun 5, 2003·Journal of Pediatric Surgery·Anna Piaseczna PiotrowskaPrem Puri
Sep 12, 2012·Nature Reviews. Gastroenterology & Hepatology·Kenton M SandersSean M Ward
Dec 25, 2004·Physiological Reviews·Steven C HebertWenhui Wang
Dec 17, 2009·Archives of Histology and Cytology·Satoshi Iino, Yoshiaki Nojyo
Oct 23, 2013·The Journal of Physiology·Salah A BakerKenton M Sanders
Sep 14, 2014·The Journal of Physiology·Yoshihiko KitoKenton M Sanders
Oct 6, 2010·The Journal of Physiology·Kenton M SandersSean M Ward
Dec 22, 2010·The Journal of Physiology·Masaaki KurahashiKenton M Sanders
Jul 8, 2008·European Journal of Pharmacology·Kiyomi HagiTadayoshi Takeuchi
Oct 6, 2005·Journal of Cellular and Molecular Medicine·R J Lang, M F Klemm
Jun 2, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M GroverG Farrugia
Jan 10, 2012·Journal of Cellular and Molecular Medicine·Masaaki KurahashiKenton M Sanders
Jun 26, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sang Don KohK M Sanders
Nov 15, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A M DuffyK D Keef
Oct 25, 2013·Journal of Cellular and Molecular Medicine·Maria-Giuliana VannucchiMaria-Simonetta Faussone-Pellegrini
Dec 18, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H Tamada, H Hashitani
Oct 2, 2015·Journal of Neurogastroenterology and Motility·Miroslav RadulovicBing Gong
Aug 16, 2016·Journal of Theoretical Biology·Jing Wui YeohMartin L Buist
Aug 5, 2016·Physiology·Kenton M SandersSean M Ward
Mar 10, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N-N SongW-X Xu
May 5, 2005·Canadian Journal of Physiology and Pharmacology·Kevin S Thorneloe, Mark T Nelson
Jul 16, 2008·Physiological Reviews·Dirk Heitzmann, Richard Warth
Mar 31, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Simona E CarboneSimon J H Brookes
Jul 6, 2014·Physiological Reviews·Kenton M SandersSang Don Koh
Aug 25, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoshihiko Kito, Noriyoshi Teramoto
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoshihiko Kito, Hikaru Suzuki
Jan 17, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ji Yeon LeePoong-Lyul Rhee
Jun 12, 2021·Autonomic Neuroscience : Basic & Clinical·Brian F King
Jun 20, 2021·Autonomic Neuroscience : Basic & Clinical·Kenton M Sanders, Violeta N Mutafova-Yambolieva

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