PMID: 9185142Jul 1, 1997Paper

Distribution of capsular types and antimicrobial susceptibility of invasive isolates of Streptococcus pneumoniae in Colombian children. Pneumococcal Study Group in Colombia

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
E CastañedaA Homma

Abstract

Streptococcus pneumoniae is the leading bacterial cause of childhood pneumonia in the developing world. This study describes the type distribution and antimicrobial susceptibility of invasive pneumococcal isolates from Colombian children and is part of the Sistema Regional de Vacunas (SIREVA), a PAHO regional initiative designed to determine the ideal serotype composition of a protein polysaccharide pneumococcal conjugate vaccine for use in children less than 5 years old in Latin America. In Colombia, during the study period, centres in Bogota, Medellin, and Cali collected 324 S. pneumoniae isolates from invasive diseases, 238 (73.5%) from children under the age of 2. Pneumonia was the clinical diagnosis in 41.3% cases, meningitis in 41%, and sepsis in 11.2%. The seven most frequent types included 14(21.9%), 5(10.5%), 23F(9.6%), 1(9%), 6B(9%), 19F(7.1%), and 6A(6.2%). The frequency of diminished susceptibility to penicillin (DSP) was 12%, with 8.9% of isolates showing intermediate level resistance and 3.1% showing high level resistance. Among DSP isolates, 23% were also resistant to cefotaxime, 33.3% to erythromycin, 48.7% to chloramphenicol, and 74.3% to trimethoprim/sulfamethoxazole. Multiple resistance was detected in 59% of...Continue Reading

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Citations

Mar 6, 1999·Current Opinion in Microbiology·J B McCormick
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
Jul 10, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M C VelaE Castañeda
Feb 2, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M HortalUNKNOWN PAHO SIREVA-Vigía Study Group
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M C BrandileoneA Tomasz
Sep 3, 1998·The Pediatric Infectious Disease Journal·A ArguedasE Mohs
Jul 13, 2004·The Pediatric Infectious Disease Journal·James D CampbellMyron M Levine
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Dec 19, 2001·Emerging Infectious Diseases·M C Vela CoralD E Briles
Apr 12, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Michele Nurse-LucasPatrick Eberechi Akpaka
Nov 24, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Erica L DuegerNeal Halsey
Apr 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J HobanR N Jones
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E CastañedaA Tomasz
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A RossiA Tomasz
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G Echániz-AvilesA Tomasz

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