Distribution of convergent afferents innervating bladder and prostate at dorsal root Ganglia in rats

Urology
Yong ChenJianhua Zhang

Abstract

To investigate the distribution of dichotomizing afferents supplying both the prostate and urinary bladder, and to discern the effects of noxious stimulation of the prostate on urinary bladder function in rats. Dual retrograde fluorescence labeling was used to investigate the neurogenic aspect of urinary bladder function. The dual distribution of dorsal root ganglia (DRG) cells was determined by propidium iodide (PI) and propidium bisbenzimide (Bb) staining into the prostate and bladder. To examine mechanical sensitivity of the bladder, conscious filling cystometry was performed before and after completion of Freund adjuvant injection into the prostate. Double-labeled positive cells were found in the lumbosacral DRG, predominantly in L1-L2 and L6-S1, with distribution varyinig from 7.5% to 14%. Most of the double-labeled cells were classified as small and medium in size. Prostatic irritation had no effect on the number of labeled cells. With the use of cystometry, prostatic irritation was found to shorten mean micturition interval (P <.05), decrease mean volume threshold inducing micturition, and increase baseline pressure and threshold pressure (P <.05), but to lower peak micturition pressure compared with that in controls (P ...Continue Reading

References

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Citations

Mar 25, 2014·Pain Management·Mercy A Udoji, Timothy J Ness
Mar 1, 2015·Experimental Neurology·Sophie C PayneJanet R Keast
Oct 26, 2011·The Prostate·Tiiu KullisaarReet Mändar
Jul 3, 2013·Autonomic Neuroscience : Basic & Clinical·Donna M DalyDavid Grundy

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