Abstract
To investigate the distribution of dichotomizing afferents supplying both the prostate and urinary bladder, and to discern the effects of noxious stimulation of the prostate on urinary bladder function in rats. Dual retrograde fluorescence labeling was used to investigate the neurogenic aspect of urinary bladder function. The dual distribution of dorsal root ganglia (DRG) cells was determined by propidium iodide (PI) and propidium bisbenzimide (Bb) staining into the prostate and bladder. To examine mechanical sensitivity of the bladder, conscious filling cystometry was performed before and after completion of Freund adjuvant injection into the prostate. Double-labeled positive cells were found in the lumbosacral DRG, predominantly in L1-L2 and L6-S1, with distribution varyinig from 7.5% to 14%. Most of the double-labeled cells were classified as small and medium in size. Prostatic irritation had no effect on the number of labeled cells. With the use of cystometry, prostatic irritation was found to shorten mean micturition interval (P <.05), decrease mean volume threshold inducing micturition, and increase baseline pressure and threshold pressure (P <.05), but to lower peak micturition pressure compared with that in controls (P ...Continue Reading
References
Jul 1, 1991·Urology·J N Krieger, K J Egan
Apr 1, 1993·Urology·J J de la RosetteF M Debruyne
Nov 5, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Seiji OhtoriHideshige Moriya
Nov 11, 2005·The Journal of Urology·Yong ChenJian-Hua Zhang
Jan 13, 2006·American Journal of Physiology. Renal Physiology·Elena E UstinovaMichael A Pezzone
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenneth P WinnardKaren J Berkley
Sep 12, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A P MalykhinaH I Akbarali
Oct 31, 2006·Pain·Julie A ChristiansonMichael A Pezzone
Feb 17, 2007·Experimental Neurology·Li-Ya Qiao, John R Grider
Apr 18, 2007·The Journal of Urology·Martin MarszalekStephan Madersbacher
Apr 28, 2007·Urology·C Lowell Parsons
Aug 8, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Ayman A HassanKhalid Salem
Oct 9, 2007·Neuroscience·A P Malykhina
Jun 20, 2008·Urology·Nobuhiro HagaOsamu Yamaguchi
Dec 19, 2008·The New England Journal of Medicine·J Curtis NickelUNKNOWN Chronic Prostatitis Collaborative Research Network
May 12, 2009·Urology·Bo SongLongkun Li
Citations
Mar 25, 2014·Pain Management·Mercy A Udoji, Timothy J Ness
Mar 1, 2015·Experimental Neurology·Sophie C PayneJanet R Keast
Mar 5, 2016·The Prostate·Sanghee LeeWade Bushman
Jun 29, 2012·The Journal of Comparative Neurology·D RussoR Chiocchetti
Oct 26, 2011·The Prostate·Tiiu KullisaarReet Mändar
Mar 22, 2016·The Journal of Urology·Erica S SchwartzG F Gebhart
Jul 3, 2013·Autonomic Neuroscience : Basic & Clinical·Donna M DalyDavid Grundy
Feb 10, 2017·The Prostate·Shinsuke MizoguchiHiromitsu Mimata
Jan 23, 2019·The Journal of Physiology·Yasuhito FunahashiNaoki Yoshimura
Nov 20, 2020·Endocrinology·Laura E PascalZhou Wang
Jan 20, 2021·The Prostate·Ozgu AydogduMichael Winder
Jan 30, 2021·Endocrinology·Laura E PascalZhou Wang
Aug 23, 2021·BMC Urology·Ozgu AydogduMichael Winder