PMID: 6983685Sep 1, 1982Paper

Distribution of CRF-like immunoreactivity in the rabbit

Peptides
A J Fischman, R L Moldow

Abstract

CRF-like immunoreactivity was measured by radioimmunoassay in the brains and gastroenteropancreatic tract of normal rabbits. It was detected in the brain, with the highest concentration being found in the ventral hypothalamus. The distribution of immunoreactivity was much more limited in the rabbit brain than in the rat brain, with substantial amounts of peptide detected only in areas of close proximity to the hypothalamus, e.g., thalamus, preoptic area, midbrain and amygdala. In addition, the extrahypothalamic immunoreactivity was slightly retarded on Sephadex G-50 chromatography relative to rat CRF-like immunoreactivity and synthetic ovine CRF. No apparent CRF-like immunoreactivity was detected in boiling water extracts of lung, pancreas, duodenum or antrum. These data in conjunction with a previous repeat of void volume immunoreactivity on Sephadex G-50 only in the hypothalamus suggest that CRF is synthesized only in the hypothalamus and is not a member of the class of peptides found throughout the gastroenteropancreatic tract and the central nervous system.

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Moldow, R S Yalow
May 22, 1978·Life Sciences·R L Moldow, R S Yalow
Oct 28, 1977·Annals of the New York Academy of Sciences·A Brodish
Jun 1, 1975·Endocrinology·M BrownsteinJ S Kizer
Mar 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R L Moldow, R S Yalow
Jan 1, 1981·Peptides·C M TurkelsonM Shimizu
Jan 1, 1981·Peptides·R S Yalow, J Eng
Jan 1, 1982·Peptides·R L Moldow, A J Fischman

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Citations

Jan 1, 1991·Brain Research Bulletin·E Tarjan, D A Denton

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