Distribution of CYP1A1*2A polymorphism in adult patients with acute lymphoblastic leukemia in a Mexican population

Blood Cells, Molecules & Diseases
M P Gallegos-ArreolaG M Zúñiga-González

Abstract

The effects of the CYP1A1*2A genotype on susceptibility to leukemia have received particular attention in recent years because this enzyme plays a central role in the activation of carcinogens. Several polymorphisms at the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We evaluated the role of the CYP1A1*2A genotype in adults with acute lymphoblastic leukemia (ALL) by genotyping 210 patients and 228 healthy controls from the Mexican population. The frequency of the CC genotype was 8% (18/228) in the control group and 42% (88/210) in ALL patients; the frequency of the CT genotype was 39% (89/228) and 29.5% (62/210), respectively; and that of the TT genotype was 53% (121/228) and 28.5% (60/210), respectively. The odds ratio was 8.4 (95% CI, 4.7-15.5; P < 0.001). These data indicate that the CYP1A1*2A genotype contributes significantly to susceptibility to adult ALL in a sample of the Mexican population.

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Citations

Sep 3, 2008·Journal of Assisted Reproduction and Genetics·Yi YeYi-Ping Hou
Jul 7, 2011·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·K J SuneethaT Rajkumar
Apr 2, 2008·Blood Cells, Molecules & Diseases·Martha Patricia Gallegos ArreolaGuillermo Moisés Zúñiga-González
Mar 11, 2016·Indian Journal of Cancer·A BagN Bag
Oct 23, 2013·Drug Metabolism and Drug Interactions·Martha Sosa-Macías, Adrián Llerena
May 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ryan M SwinneyGail E Tomlinson
Apr 16, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Duangjai PiwkhamJoke Beuten

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