Distribution of divalent metal transporter-1 in the monkey basal ganglia

Neuroscience
En HuangJ R Connor

Abstract

An accumulation of iron occurs in the brain with age, and it is thought that this may contribute to the pathology of certain neurodegenerative diseases, including Parkinson's disease. In this study, we elucidated the distribution of divalent metal transporter-1 (DMT1) in the monkey basal ganglia by immunocytochemistry, and compared it with the distribution of ferrous iron in these nuclei by Turnbull's Blue histochemical staining. We observed a general correlation between levels of DMT1, and iron staining. Thus, regions such as the caudate nucleus, putamen, and substantia nigra pars reticulata contained dense staining of DMT1 in astrocytic processes, and were also observed to contain large numbers of ferrous iron granules. The exceptions were the globus pallidus externa and interna, which contained light DMT1 staining, but large numbers of ferrous iron granules. The thalamus, subthalamic nucleus, and substantia nigra pars compacta contained neurons that were lightly stained for DMT1, but few or no iron granules. The high levels of DMT1 expression in some of the nuclei of the basal ganglia, particularly the caudate nucleus, putamen, and substantia nigra pars reticulata, may account for the high levels of iron in these regions.

References

Jun 14, 1996·Neuroscience Letters·P D Griffiths, A R Crossman
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D FlemingN C Andrews

❮ Previous
Next ❯

Citations

Nov 4, 2010·Neurochemical Research·Abdur RahmanGilles J Guillemin
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Julio SalazarEtienne C Hirsch
Sep 21, 2013·Annual Review of Pharmacology and Toxicology·Samuel M Goldman
Feb 18, 2012·Metallomics : Integrated Biometal Science·Ebany J Martinez-FinleyMichael Aschner
Jun 6, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Silvia ZoniRoberto Lucchini
May 18, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sudipta Chakraborty, Michael Aschner
Jun 15, 2010·Progress in Neurobiology·K L DoubleG M Halliday
Jun 21, 2008·Neurotoxicology·Catherine AuMichael Aschner
Sep 18, 2007·Progress in Neurobiology·Ya Ke, Zhong Ming Qian
Oct 24, 2007·Journal of Neurochemistry·Torben MoosEvan H Morgan
May 19, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lan XiongGuy A Rouleau
Oct 13, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kenneth B Storey
Apr 4, 2016·Molecular Neurobiology·Hong JiangJunxia Xie
May 20, 2015·Journal of Neurochemistry·Pan ChenMichael Aschner
May 15, 2015·Annual Review of Nutrition·Kyle J HorningMichael Aschner
May 30, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Gyuri KimMihi Yang
Nov 9, 2012·Acta Biologica Hungarica·A RahmanSreeja Attur
Apr 23, 2016·Environmental Science and Pollution Research International·Pan ChenMichael Aschner
Aug 16, 2006·Biochimica Et Biophysica Acta·Yaniv Nevo, Nathan Nelson
Feb 1, 2011·Journal of the Neurological Sciences·Hélène BlascoUNKNOWN French ALS study group
Aug 20, 2014·Frontiers in Genetics·Pan ChenMichael Aschner
Oct 22, 2016·Medical Mycology Case Reports·Jennifer SnaithN Wah Cheung
Nov 7, 2016·BMC Pharmacology & Toxicology·Tanara V PeresMichael Aschner
Jun 14, 2019·Biological Reviews of the Cambridge Philosophical Society·Zhong-Ming Qian, Ya Ke
Sep 25, 2019·International Journal of Environmental Research and Public Health·Airton Cunha MartinsMichael Aschner
Nov 22, 2008·Biochemical Society Transactions·Ilaria PelizzoniFranca Codazzi
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivan Nyarko-DanquahEunsook Lee
Jan 24, 2020·Neurochemistry International·Mahfuzur R MiahMichael Aschner
Apr 6, 2021·Movement Disorders Clinical Practice·Takashi OgawaNobutaka Hattori
May 7, 2021·Communications Biology·Wenzheng GuanBaoman Li
Jun 18, 2021·Seminars in Cancer Biology·Peter W HalcrowJoyce E Ohm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.