Distribution of drugs in various tissues in a brain dead man

Forensic Science International : Synergy
N JitsufuchiNoriaki Ikeda

Abstract

We examined the distribution of drugs in a 49-year-old brain-dead man. Our objective was to determine the possibility of diagnosing how and at what point the patient became brain dead. The presence of mepivacaine, pentazocine, lidocaine and thiamylal in various tissues, including seven regions of the brain were confirmed, using gas chromatography/mass spectrometry. Tissue-to-blood concentration ratios of mepivacaine, pentazocine and lidocaine in the brain were higher than these ratios in other tissues, while ratios of thiamylal were lower. Therefore, cerebral blood flow was likely to have ceased between the administration of the former drugs and that of the latter drug, in agreement with clinical records. Among seven regions of the brain, the ratios of the former three drugs were high in occipital and parietal lobes, and were low in the cerebellum and medulla oblongata. On the other hand, the ratios of the latter drug were high in the cerebellum and the medulla oblongata. Therefore, cerebral blood flow presumably ceased first in occipital and parietal lobes, and last in the cerebellum and the medulla oblongata. Based on these results, assessment of concentrations of drugs in human tissues, including various regions of brain is ...Continue Reading

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Citations

Mar 23, 2002·Forensic Science International : Synergy·Akiko KiyoshimaNoriaki Ikeda
Feb 15, 2005·Legal Medicine·Akiko KiyoshimaNoriaki Ikeda
May 13, 2004·Journal of Pharmaceutical and Biomedical Analysis·M BaniceruS M Popescu
Jan 27, 2015·Biomedical Chromatography : BMC·Reinhard OertelJörg Pietsch
Jun 18, 2019·Drug Testing and Analysis·Raimo A Ketola, Pirkko Kriikku
Dec 4, 2004·The American Journal of Forensic Medicine and Pathology·Fumio Moriya, Yoshiaki Hashimoto
Aug 3, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·A KiyoshimaN Ikeda
Jun 29, 1999·Analytical Chemistry·T A BrettellR Saferstein

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