PMID: 9524190May 9, 1998Paper

Distribution of dystroglycan in normal adult mouse tissues

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
M DurbeejP Ekblom

Abstract

Dystroglycan is a cell surface protein which, in muscle, links the extracellular matrix protein laminin-2 to the intracellular cytoskeleton. Dystroglycan also binds laminin-1 and the binding occurs via the E3 fragment of laminin-1. Recently, it was found that dystroglycan is expressed in developing epithelial cells of the kidney. Moreover, antibodies against dystroglycan can perturb epithelial development in kidney organ culture. Therefore, dystroglycan may be an important receptor for cell-matrix interactions in non-muscle tissues. However, information about the tissue distribution of dystroglycan is limited, especially in adult tissues. Here we show that dystroglycan is present in epithelial cells in several non-muscle organs of adult mice. Dystroglycan is enriched towards the basal side of the epithelial cells that are in close contact with basement membranes. We suggest that dystroglycan is involved in linking basement membranes to epithelial and muscle cells. Dystroglycan may be important for the maintenance of tissue integrity.

References

Sep 20, 1991·Cell·J M Ervasti, K P Campbell
Aug 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P L Durham, J M Snyder
Dec 1, 1995·The Journal of Biological Chemistry·J H MinerJ R Sanes
May 1, 1995·The Journal of Cell Biology·C H StreuliM J Bissell
Jun 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I VirtanenM Korhonen
Jul 1, 1995·The Journal of Cell Biology·M DurbeejP Ekblom
Sep 1, 1994·Human Molecular Genetics·D C GóreckiE A Barnard
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·H XuE Engvall
Oct 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J N SchofieldY H Edwards
Feb 16, 1996·The Journal of Biological Chemistry·E A PallJ M Ervasti
Oct 1, 1996·Current Opinion in Cell Biology·P Ekblom
Oct 1, 1996·Current Opinion in Cell Biology·M D Henry, K P Campbell
Dec 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·M DurbeejM Ekblom
Feb 12, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L M SorokinP Ekblom

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Citations

Feb 7, 2001·The Journal of Comparative Neurology·H MoukhlesS Carbonetto
Feb 19, 2000·Microscopy Research and Technique·S C WatkinsL Billington
Oct 31, 2000·Microscopy Research and Technique·J StutzmannP Simon-Assmann
May 16, 2002·Microscopy Research and Technique·Matthias Kretzler
Aug 22, 2009·Cell and Tissue Research·Eva KorposLydia Sorokin
Nov 16, 2002·Hearing Research·Denise LaMarche HeaneyAndrew S Niedzielski
Mar 6, 2003·Hearing Research·Denise LaMarche Heaney, Bradley A Schulte
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·R FleischmajerY Yamada
Dec 23, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M FalkP Ekblom
Nov 18, 1998·Current Opinion in Cell Biology·M DurbeejK P Campbell
Oct 6, 1999·Current Opinion in Cell Biology·M D Henry, K P Campbell
Jun 22, 2002·Current Opinion in Genetics & Development·Madeleine Durbeej, Kevin P Campbell
Jan 23, 2013·Nature Reviews. Nephrology·Norman Sachs, Arnoud Sonnenberg
Jan 19, 2002·Differentiation; Research in Biological Diversity·M DurbeejP Ekblom
Aug 25, 2001·Journal of Neurochemistry·H Moukhles, S Carbonetto
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Scott N Mueller, Rafi Ahmed
May 12, 2009·Glycobiology·Mark Lommel, Sabine Strahl
Jan 14, 2012·Glycobiology·Rebecca HarrisonStuart M Haslam
Jan 26, 1999·Annals of the New York Academy of Sciences·M EkblomP Ekblom
Apr 18, 2008·Journal of Virology·Douglas E DyllaPaul B McCray
Jan 15, 2010·Journal of Virology·Katrin SchlieWolfgang Garten
May 6, 2011·American Journal of Physiology. Renal Physiology·Daniel Kai Long Tham, Hakima Moukhles
Jan 7, 2011·American Journal of Physiology. Renal Physiology·George JaradJeffrey H Miner
Feb 13, 2001·American Journal of Respiratory Cell and Molecular Biology·S R WhiteD R Dorscheid
Oct 14, 2010·Journal of Cell Science·Dmitri LeonoudakisJohn L Muschler
Oct 1, 2010·Therapeutic Delivery·V Mangas-SanjuanM Bermejo
Jan 29, 2014·The Journal of Cell Biology·Yoshimitsu KanaiNobutaka Hirokawa
Sep 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Scott N MuellerRafi Ahmed
Sep 26, 2009·Seminars in Immunopathology·Britta Engelhardt, Lydia Sorokin

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