PMID: 499309Sep 1, 1979Paper

Distribution of elimination of hydroflumethiazide in man

European Journal of Clinical Pharmacology
O Brørs, S Jacobsen

Abstract

The pharmacokinetics of hydroflumethiazide (HFT) were investigated after intravenous and oral administration to healthy subjects. After intravenous infusion, HFT behaved according to a three-compartment model. Two distribution phases were observed, with mean half-lives of 0.26 and 0.85 h, reflecting distribution to red blood cells and tissues. Mean biological half-life (t 1/2 beta) after infusion was 5.2 h. Renal blood and plasma clearance of HFT, as well as the ratio renal blood clearance/renal plasma clearance of HFT, were lower after infusion than during the infusion, due to the distribution characteristics of HFT. After a single oral dose of 2 micronmol/kg, t 1/2 beta was significantly shorter in all subjects than after a single oral dose of 6 micronmol/kg, with mean t 1/2 beta of 8.7 and 17.9 h, respectively. Due to lack of a sufficiently sensitive method for determination of HFT in plasma, it could not be established whether the observed dose-dependent difference in biological half-life of HFT was caused by variation in renal clearance and/or the volume of distribution.

References

May 21, 1979·European Journal of Clinical Pharmacology·O Brørs, S Jacobsen
May 21, 1979·European Journal of Clinical Pharmacology·O BrørsS Jacobsen
Apr 1, 1978·Journal of Clinical Pharmacology·P J McNamaraM Gibaldi
Nov 9, 1978·European Journal of Clinical Pharmacology·O BrørsE Arnesen
Aug 1, 1975·The Journal of Infectious Diseases·M BarzaL Weinstein
Jan 1, 1977·Journal of Clinical Pharmacology·G J YakatanJ T Doluisio
Jan 3, 1977·European Journal of Clinical Pharmacology·O BrorsE Arnesen
Oct 1, 1975·Clinical Pharmacology and Therapeutics·G R Wilkinson, D G Shand
Nov 1, 1974·Journal of Pharmaceutical Sciences·Y GarceauJ Hasegawa

Citations

Jan 1, 1989·Annals of the New York Academy of Sciences·C PetersonJ Goldman
Nov 1, 1986·Biopharmaceutics & Drug Disposition·P G Welling
Jan 1, 1981·European Journal of Clinical Pharmacology·L BalantJ Fabre

Related Concepts

Dose-Response Relationship, Drug
Half-Life
Diucardin
Intravenous Injections
Kidney
Drug or Chemical Tissue Distribution

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