Distribution of ELOVL4 in the Developing and Adult Mouse Brain

Frontiers in Neuroanatomy
David M SherryRobert E Anderson

Abstract

ELOngation of Very Long chain fatty acids (ELOVL)-4 is essential for the synthesis of very long chain-fatty acids (fatty acids with chain lengths ≥ 28 carbons). The functions of ELOVL4 and its very long-chain fatty acid products are poorly understood at present. However, mutations in ELOVL4 cause neurodevelopmental or neurodegenerative diseases that vary according to the mutation and inheritance pattern. Heterozygous inheritance of different ELOVL4 mutations causes Stargardt-like Macular Dystrophy or Spinocerebellar Ataxia type 34. Homozygous inheritance of ELOVL4 mutations causes more severe disease characterized by seizures, intellectual disability, ichthyosis, and premature death. To better understand ELOVL4 and very long chain fatty acid function in the brain, we examined ELOVL4 expression in the mouse brain between embryonic day 18 and postnatal day 60 by immunolabeling using ELOVL4 and other marker antibodies. ELOVL4 was widely expressed in a region- and cell type-specific manner, and was restricted to cell bodies, consistent with its known localization to endoplasmic reticulum. ELOVL4 labeling was most prominent in gray matter, although labeling also was present in some cells located in white matter. ELOVL4 was widely ex...Continue Reading

References

Jun 15, 1996·The Biochemical Journal·N P RotsteinM I Aveldaño
Oct 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H K WolfI Blümcke
Feb 15, 2001·Nature Genetics·X ZhangY Shen
Jul 23, 2005·The Journal of Biological Chemistry·Celene Grayson, Robert S Molday
Jan 19, 2006·Biochemical Society Transactions·E Marza, G M Lesa
Dec 8, 2006·Nature·Ed S LeinAllan R Jones
Feb 17, 2007·International Journal of Biological Sciences·D Joshua CameronKang Zhang
Dec 21, 2007·Molecular Biology of the Cell·Esther MarzaGiovanni M Lesa
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin-Paul AgbagaRobert E Anderson
Mar 20, 2010·Journal of Lipid Research·Martin-Paul AgbagaRobert E Anderson
Nov 22, 2011·American Journal of Human Genetics·Mohammed A AldahmeshFowzan S Alkuraya
Mar 10, 2012·Human Molecular Genetics·Alexander BroddeWilhelm W Just
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sreemathi LoganRobert E Anderson
Feb 27, 2014·Journal of Lipid Research·Sreemathi LoganRobert E Anderson
Mar 26, 2014·Advances in Experimental Medicine and Biology·L D MarchetteN A Mandal
Mar 29, 2014·Investigative Ophthalmology & Visual Science·Anne McMahonIgor A Butovich
Apr 12, 2014·Investigative Ophthalmology & Visual Science·Lea D BennettRobert E Anderson
Aug 11, 2015·JAMA Neurology·Cynthia V BourassaGuy A Rouleau
Oct 26, 2016·Developmental Cell·Catherine L JacksonJean-Marc Verbavatz
Dec 3, 2016·Nature Reviews. Neuroscience·Lucile Ben Haim, David H Rowitch
Feb 17, 2017·Journal of Lipid Research·Blake R HopiavuoriRobert E Anderson

❮ Previous
Next ❯

Citations

Oct 17, 2019·Frontiers in Cellular Neuroscience·Ferenc DeákDavid M Sherry
Feb 9, 2021·Journal of Lipid Research·Gyening Kofi YeboahMartin-Paul Agbaga
May 18, 2021·Frontiers in Neuroanatomy·Ilaria BalboEriola Hoxha
Aug 8, 2021·International Journal of Molecular Sciences·Aida V Garcia CorralesJerome J A Hendriks

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence imaging
fluorescence microscopy

Key Resources (RRID) Mentioned

AB_2109815
AB_2110656
AB_177621
AB_143011
AB_138404
AB_2534017

Software Mentioned

CellSens
QCapture
Photoshop

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.