Distribution of embutramide and mebezonium iodide in a suicide after tanax injection

Journal of Analytical Toxicology
L MoriniA Groppi

Abstract

Tanax is a veterinary formulation for euthanasia comprising embutramide, mebezonium iodide and tetracaine. A 37-year-old female was found dead on her bed, with three empty used syringes and a bottle of Tanax beside her body. Three needle puncture marks were observed on the body. The aim of this study was to evaluate the distribution of embutramide and mebezonium iodide in different biological matrices (femoral and cardiac blood, liver, muscle and vitreous humor) using a chromatographic method for the simultaneous determination of the two drugs. A direct and sensitive liquid chromatography-tandem mass spectrometry method was developed in multiple reaction monitoring mode with positive ionization. Lidocaine was used as an internal standard. Limits of detection and quantitation of 0.01 and 0.05 mg/L, respectively, were reached for both compounds. Embutramide levels ranged from 2.74 mg/L in vitreous humor to 5.06 mg/L in femoral blood, while mebezonium iodide was found at widely differing concentrations (ranging from 2.80 mg/kg in muscle to 24.80 mg/kg in liver). The chromatographic method developed for this study provides a very simple and sensitive means for the simultaneous determination of embutramide and mebezonium iodide, the...Continue Reading

References

Nov 9, 2002·Journal of Analytical Toxicology·P KintzB Ludes
Jun 20, 2006·Forensic Science International : Synergy·Frank T PetersFrank Musshoff
Jan 1, 1983·Journal of Pharmaceutical and Biomedical Analysis·E BertolA Bonelli
Sep 27, 2008·Journal of Pharmaceutical and Biomedical Analysis·M FidaniM Montana

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Citations

Jul 13, 2016·Journal of Forensic Sciences·Anikó LajtaiAttila Miseta
Jan 23, 2016·Forensic Toxicology·Fabien BévalotJérôme Guitton
Nov 19, 2014·Journal of Veterinary Pharmacology and Therapeutics·A J Perrin

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