Distribution of endosomal, lysosomal, and major histocompatability complex markers in a monocytic cell line infected with Chlamydia psittaci.

Infection and Immunity
D M OjciusA Dautry-Varsat

Abstract

The intracellular fate of Chlamydia psittaci during infection of a monocytic cell line, THP1, was characterized. Cytochalasin D inhibited phagocytosis of latex beads but had no effect on infection by C. psittaci, and vacuoles expressed the transferrin receptor, suggesting accessibility to the endocytic pathway. Early Chlamydia-containing vacuoles expressed major histocompatibility complex (MHC) class I molecules, and most vacuoles fused with host cell lysosomes, since they expressed LAMP-1 and had acidic pHs. In cells prestimulated with gamma interferon, vacuoles also expressed MHC class II molecules, suggesting that the monocytes might effectively process Chlamydia-derived antigens for presentation by MHC class I and class II molecules.

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Citations

Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S PrebeckT Miethke
Apr 13, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hiroshi NomuraToru Iwaki
Jan 9, 2007·Medical Microbiology and Immunology·Birgit Krausse-OpatzLars Köhler
Sep 17, 2015·Molecular Microbiology·Jo-Ana HerwegAdrian Mehlitz
Apr 25, 2003·International Reviews of Immunology·Kathleen A Kelly
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nuria RodriguezThomas Miethke
Mar 6, 1999·Current Opinion in Microbiology·T Hackstadt

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