PMID: 9557986Apr 29, 1998Paper

Distribution of Eph-related molecules in the developing and mature cochlea

Hearing Research
L M Bianchi, Nicholas W Gale

Abstract

Receptors and ligands of the Eph family have recently been shown to influence the development of a variety of tissues. In the present study, the temporal and spatial distribution of Eph receptors and ligands were investigated in the embryonic and postnatal cochlea using Northern blot and immunohistochemical analysis. The results of Northern blot experiments revealed that a large number of Eph family members were present in embryonic cochlear and vestibular ganglia. Immunohistochemical studies revealed that ligands and receptors of the GPI subclass were distributed in complementary patterns within the differentiating spiral limbus, inner sulcus and outer sulcus. The distribution of these molecules became more restricted beginning in the first postnatal week. In contrast, members of the transmembrane subclass of Eph ligands were largely associated with cochlear neurons and their target hair cells. Expression of these ligands appeared to increase during the second postnatal week, corresponding to the period of peripheral nerve fiber reorganization in the cochlea. Together, these studies suggest that multiple Eph family members play unique roles in formation of the cochlea.

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Citations

Apr 10, 2003·Hearing Research·James O Pickles
Dec 22, 1999·Hearing Research·W R van HeumenJ O Pickles
Oct 31, 2002·The European Journal of Neuroscience·Lynne M Bianchi, Neil A Gray
Feb 26, 2016·Hearing Research·Matthew M WallaceMark L Gabriele
Aug 2, 2015·Hearing Research·Laurence Delacroix, Brigitte Malgrange
Oct 5, 2010·Developmental Neurobiology·Mark L GabrieleSarah M Kavianpour
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Jul 17, 2015·Developmental Neurobiology·Young J KimLi I Zhang
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Jul 11, 2014·Neuroscience·K S Cramer, M L Gabriele
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Aug 6, 2005·Hearing Research·Karina S Cramer
Dec 18, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Lynne M BianchiNicholas W Gale
Feb 24, 2001·The Laryngoscope·C D CunninghamB N Schmiedt
Jan 25, 2014·Audiology & Neuro-otology·Nathanael YatesJennifer Rodger
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Aug 5, 2003·American Journal of Audiology·D M Baguley, G Andersson
May 21, 2005·American Journal of Audiology·Richard S TylerCamille C Dunn

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