Distribution of epicatechin metabolites in lymphoid tissues and testes of young rats with a cocoa-enriched diet

The British Journal of Nutrition
Mireia Urpí-SardàCristina Andres-Lacueva

Abstract

An increasing number of scientific studies support that flavanol-rich foods and beverages such as cocoa can promote human health, and are beneficial agents for the prevention of some diseases. Our previous studies showed that long-term cocoa intake enhances the antioxidant status in lymphoid organs and also modulates lymphocyte functionality in healthy young rats. Cocoa polyphenolic antioxidants seem to be the best candidates for those effects. However, data regarding polyphenol metabolites in tissues after a long-term cocoa intake are scarce. In the present study we mainly focus on the uptake and accumulation of epicatechin metabolites in lymphoid organs, including the thymus, spleen and mesenteric lymphoid nodes, as well as in the liver and testes after a diet rich in cocoa. Ten young weaned Wistar rats were fed randomly with a 10 % (w/w) cocoa diet or a control diet for 3 weeks, corresponding to their infancy and youth. Tissues were treated with a solid-phase extraction and analysed by liquid chromatography-tandem MS. The major compounds recovered in these tissues were glucuronide derivatives of epicatechin and methylepicatechin. The highest concentration of these metabolites was found in the thymus, testicles and liver, fol...Continue Reading

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Citations

Apr 8, 2011·Antioxidants & Redox Signaling·David L KatzAther Ali
Aug 9, 2011·Bioscience, Biotechnology, and Biochemistry·Hiroko TakumiJunji Terao
Mar 16, 2016·Molecular Metabolism·Aleix Ribas-Latre, Kristin Eckel-Mahan
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Jul 14, 2017·Frontiers in Nutrition·Mariona Camps-BossacomaMargarida Castell
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Jan 22, 2016·Diseases·María Angeles MartínSonia Ramos
May 13, 2021·Scientific Reports·Paulo ZielinskyIzabele Vian

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