PMID: 8984830Jan 1, 1995Paper

Distribution of Escherichia coli heat-stable enterotoxin/guanylin/uroguanylin receptors in the avian intestinal tract

Acta Anatomica
W J KrauseL R Forte

Abstract

Pathogenic strains of enteric bacteria secrete small heat-stable toxins (STs) that activate membrane guanylyl cyclase receptors found in the intestine. The intestinal peptide agonists, guanylin and uroguanylin, are structurally related to STs. Receptors for 125I-ST were found throughout the entire length of the intestinal tract of all the birds examined. These receptors were restricted to intestinal epithelial cells covering villi and forming intestinal glands and were not observed in other strata of the gut wall. The most intense labeling of receptors by 125I-ST occurred in the region of the microvillus border of individual enterocytes. There appeared to be a decrease in receptor density distally along the length of the small intestine, although labeling of receptors by 125I-ST was observed throughout the small intestine and colon. Cellular cGMP accumulation responses to Escherichia coli ST and rat guanylin in the domestic turkey and duck were greater in the proximal small intestine compared to the distal small intestine or colon. Brush border membranes (BBM) isolated from the mucosa of proximal small intestine of turkeys exhibited agonist-stimulated guanylyl cyclase activity. The rank order potency for enzyme activation was E...Continue Reading

Citations

Jun 14, 2005·Pflügers Archiv : European journal of physiology·Aleksandra Sindić, Eberhard Schlatter
Aug 26, 2000·Peptides·E P Bernick, D F Stiffler
Aug 23, 2001·Nuclear Medicine and Biology·T J HoffmanW A Volkert
Jun 12, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M M ComrieG Cramb
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·G M PitariS A Waldman
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·F K HamraL R Forte
Jun 9, 2000·Annual Review of Physiology·L R ForteR H Freeman
Jun 3, 2005·Zoological Science·Mina Nakauchi, Norio Suzuki
Jun 9, 2000·Annual Review of Physiology·K E Barrett, S J Keely
Jun 23, 1997·FEBS Letters·B J Wedel, D L Garbers
Nov 11, 2006·FEMS Immunology and Medical Microbiology·Ahmad M Al-MajaliA Mahdi Saeed
Jun 15, 2007·General and Comparative Endocrinology·Yoshio Takei, Shinya Yuge
Oct 22, 2005·International Journal of Medical Microbiology : IJMM·Béla Nagy, Péter Z Fekete
Feb 5, 2008·Comparative Immunology, Microbiology and Infectious Diseases·Sophie VeilleuxJ Daniel Dubreuil
Dec 5, 2006·Current Opinion in Nephrology and Hypertension·Aleksandra Sindić, Eberhard Schlatter
Jun 11, 1999·The American Journal of Physiology·R M LondonL R Forte
May 12, 1998·The American Journal of Physiology·N S JooL L Clarke
Aug 1, 1997·General and Comparative Endocrinology·W J KrauseL R Forte

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