PMID: 7334484Nov 1, 1981Paper

Distribution of Fc gamma receptors on isolated gut enterocytes of the suckling rat

Journal of Reproductive Immunology
A E Wild

Abstract

An erythrocyte-antibody rosette assay has been used to study the presence and distribution of Fc gamma receptors on enterocytes isolated from 12-day-old suckling rat gut by means of a buffer medium containing EGTA. Such receptors were found to be restricted to enterocytes in the proximal region (duodenum and jejunum) of the small intestine and to be acid-pH dependent. For the majority of enterocytes indicator red cells bound in high density to the abluminal plasmalemma but not to the apical microvillous brush border. Since immunofluorescence studies revealed strong binding of added IgG to the microvillous region, a likely explanation is that there is a paucity of Fc gamma receptors from the tips of microvilli (at least under the conditions of the rosette assay) and that receptors more deeply situated as inaccessible to indicator red cells. Binding of indicator red cells was readily inhibited by rabbit, human, guinea pig and rat IgG but less so by bovine IgG, and of the two sub-classes, bovine IgG2 inhibited much more readily than bovine IgG1. Cortisone acetate injection virtually abolished Fc gamma receptor expression on isolated enterocytes within three days. These findings correlate both with selective transport of IgG of dif...Continue Reading

References

Jul 1, 1973·The Journal of Cell Biology·R Rodewald
Nov 1, 1972·The Journal of Clinical Investigation·E A Jones, T A Waldmann
Sep 1, 1980·The Journal of Cell Biology·C A ZiomekM Edidin
Jan 1, 1959·The Journal of Endocrinology·R HALLIDAY

❮ Previous
Next ❯

Citations

Jan 1, 1984·Folia Microbiologica·L Fornůsek, V Vĕtvicka
Jan 1, 1994·Developmental and Comparative Immunology·A E WildJ Brand
Aug 1, 1987·Journal of Reproductive Immunology·P Griffin, A E Wild

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.