Distribution of FcγR gene polymorphisms among two sympatric populations in Mali: differing allele frequencies, associations with malariometric indices and implications for genetic susceptibility to malaria

Malaria Journal
M K CherifMaiga Bakary

Abstract

Genetic polymorphisms in the complex gene cluster encoding human Fc-gamma receptors (FcγRs) may influence malaria susceptibility and pathogenesis. Studying genetic susceptibility to malaria is ideal among sympatric populations because the distribution of polymorphic genes among such populations can help in the identification malaria candidate genes. This study determined the distribution of three FcyRs single nucleotide polymorphisms (SNPs) (FcγRIIB-rs1050519, FcγRIIC-rs3933769 and FcγRIIIA-rs396991) among sympatric Fulani and Dogon children with uncomplicated malaria. The association of these SNPs with clinical, malariometric and immunological indices was also tested. This study involved 242 Fulani and Dogon volunteers from Mali age under 15 years. All SNPs were genotyped with predesigned TaqMan(®) SNP Genotyping Assays. Genotypic and allelic distribution of SNPs was compared across ethnic groups using the Fisher exact test. Variations in clinical, malariometric and immunologic indices between groups were tested with Kruskal-Wallis H, Mann-Whitney U test and Fisher exact test where appropriate. The study confirmed known malariometric and immunologic differences between sympatric Fulani and non-Fulani tribes. Parasite density w...Continue Reading

References

Aug 1, 1987·Annals of Tropical Medicine and Parasitology·B M GreenwoodR Hayes
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D ModianoM Coluzzi
Nov 5, 1999·The American Journal of Tropical Medicine and Hygiene·D ModianoF Esposito
Nov 8, 2002·Parasitology International·Kazuya OmiKatsushi Tokunaga
Jul 8, 2005·American Journal of Human Genetics·Dominic P Kwiatkowski
Apr 17, 2007·Proceedings of the National Academy of Sciences of the United States of America·Menna R ClatworthyKenneth G C Smith
Jan 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria G TorciaDavid Modiano
Oct 10, 2008·The Journal of Rheumatology·Young Ho LeeGwan Gyu Song
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lisa C WillcocksKenneth G C Smith
Dec 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joris van der HeijdenTaco W Kuijpers
Apr 21, 2012·Frontiers in Genetics·Michal Chorev, Liran Carmel

❮ Previous
Next ❯

Citations

Jun 13, 2017·The Journal of Infectious Diseases·Imad FaikThirumalaisamy P Velavan
Jul 12, 2020·Scandinavian Journal of Immunology·Marita Troye-BlombergAnn-Kristin Östlund Farrants
Nov 26, 2019·Immunological Reviews·Martin R GoodierEleanor M Riley
Dec 15, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jorge Eliécer Mario-VásquezCesar Segura
Dec 8, 2020·Frontiers in Immunology·Mireille Ahou AmiahWilliam Yavo

❮ Previous
Next ❯

Methods Mentioned

BETA
Genotyping
PCR
ELISA

Software Mentioned

SoftMax ® Pro
Stata

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.