Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: in situ hybridisation histochemistry and receptor autoradiography

Neurochemistry International
F ChenA J Lawrence

Abstract

The present study has employed quantitative receptor autoradiography and in situ hybridisation histochemistry to compare the expression of the mRNA encoding the alpha 1 and alpha 2 subunits of the GABAA receptor and the binding density of mature GABAA receptors in the limbic system of alcohol-preferring Fawn-Hooded rats (FH) with Wistar-Kyoto rats (WKY). Quantifiable levels of mRNA encoding the alpha 1 subunit were found in cortical regions, ventral pallidum, substantia nigra, horizontal limb of the diagonal band and the hippocampus of both rat strains. Interestingly, expression of the alpha 1 subunit mRNA was decreased by approximately 30% in the hippocampus of FH compared to WKY rats. Following a 28-day period with free access to 10% ethanol, expression of the alpha 1 subunit transcript, was significantly increased in the piriform cortex and horizontal limb of the diagonal band, unaltered in the hippocampus but decreased in the substantia nigra of FH rats. Quantifiable levels of mRNA encoding the alpha 2 subunit were found in nucleus accumbens, amygdala, cortical regions, lateral septal nucleus, hippocampus, medial habenula and ventral pallidum of both strains. Expression of the alpha 2 subunit mRNA was decreased by approxima...Continue Reading

References

Jul 1, 1975·Journal of Neurochemistry·I A SytinskyN N Konovalova
Dec 8, 1992·The Journal of Comparative Neurology·E PersohnJ G Richards
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P D SuzdakS M Paul
Dec 1, 1989·Neuron·M KhrestchatiskyA J Tobin
Jun 30, 1988·Biochemical and Biophysical Research Communications·M Bureau, R W Olsen
Jun 15, 1969·Experientia·N R Banna
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·L L DevaudG E Duncan
Dec 15, 1993·The Journal of Comparative Neurology·W MaJ L Barker
Mar 1, 1995·Journal of Psychiatric Research·H Lüddens, E R Korpi
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·R A HarrisT V Dunwiddie
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·R L KleinR A Harris
Feb 1, 1997·British Journal of Pharmacology·M Ashworth-PreeceA J Lawrence
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·M CowenA J Lawrence

❮ Previous
Next ❯

Citations

Dec 28, 1999·European Journal of Pharmacology·F ChenA J Lawrence
Oct 20, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·W P ParéJ Kluczynski
Dec 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·M S Cowen, A J Lawrence
Feb 17, 1998·Neuroscience Letters·F ChenA J Lawrence
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·F Chen, A J Lawrence
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·M S Cowen, A J Lawrence
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Jennifer Lynn ShortAndrew John Lawrence
Aug 18, 2004·Neuroscience·T Featherby, A J Lawrence
Sep 20, 2006·Neuroscience and Biobehavioral Reviews·David H OverstreetAndrew J Lawrence
May 20, 2014·Drug and Alcohol Dependence·P J RyanA J Lawrence
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer Lynn ShortAndrew John Lawrence
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Elvan Djouma, Andrew J Lawrence

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.