Abstract
The present study has employed quantitative receptor autoradiography and in situ hybridisation histochemistry to compare the expression of the mRNA encoding the alpha 1 and alpha 2 subunits of the GABAA receptor and the binding density of mature GABAA receptors in the limbic system of alcohol-preferring Fawn-Hooded rats (FH) with Wistar-Kyoto rats (WKY). Quantifiable levels of mRNA encoding the alpha 1 subunit were found in cortical regions, ventral pallidum, substantia nigra, horizontal limb of the diagonal band and the hippocampus of both rat strains. Interestingly, expression of the alpha 1 subunit mRNA was decreased by approximately 30% in the hippocampus of FH compared to WKY rats. Following a 28-day period with free access to 10% ethanol, expression of the alpha 1 subunit transcript, was significantly increased in the piriform cortex and horizontal limb of the diagonal band, unaltered in the hippocampus but decreased in the substantia nigra of FH rats. Quantifiable levels of mRNA encoding the alpha 2 subunit were found in nucleus accumbens, amygdala, cortical regions, lateral septal nucleus, hippocampus, medial habenula and ventral pallidum of both strains. Expression of the alpha 2 subunit mRNA was decreased by approxima...Continue Reading
References
Jul 1, 1975·Journal of Neurochemistry·I A SytinskyN N Konovalova
Dec 8, 1992·The Journal of Comparative Neurology·E PersohnJ G Richards
Apr 1, 1992·Neurochemical Research·M NegroP Calvo
May 1, 1992·Journal of Neurochemistry·M NegroP Calvo
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P D SuzdakS M Paul
Sep 22, 1989·Science·D B PritchettP H Seeburg
Dec 1, 1989·Neuron·M KhrestchatiskyA J Tobin
Jun 30, 1988·Biochemical and Biophysical Research Communications·M Bureau, R W Olsen
Oct 1, 1986·Neuropharmacology·S K RastogiM K Ticku
Jun 1, 1987·Journal of Neurochemistry·M HeaulmeK Biziere
Sep 1, 1987·Journal of Neurochemistry·R NiddamS Z Langer
Jun 15, 1969·Experientia·N R Banna
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·L L DevaudG E Duncan
Dec 15, 1993·The Journal of Comparative Neurology·W MaJ L Barker
Mar 1, 1995·Journal of Psychiatric Research·H Lüddens, E R Korpi
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·R A HarrisT V Dunwiddie
Oct 1, 1993·Journal of Neurochemistry·M H Bureau, R W Olsen
Sep 1, 1995·Neuropharmacology·M NegroP Calvo
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·R L KleinR A Harris
Dec 1, 1995·Synapse·J OrtizE J Nestler
Feb 1, 1997·British Journal of Pharmacology·M Ashworth-PreeceA J Lawrence
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·M CowenA J Lawrence
Citations
Dec 28, 1999·European Journal of Pharmacology·F ChenA J Lawrence
Nov 12, 2003·Hormones and Behavior·Jill M GrimesRichard H Melloni
May 14, 2003·Behavioural Brain Research·Daniel J Lodge, Andrew J Lawrence
May 4, 2000·Peptides·D J LodgeA J Lawrence
Jun 29, 2000·Neurochemistry International·A C GrobinA L Morrow
Oct 20, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·W P ParéJ Kluczynski
Dec 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·M S Cowen, A J Lawrence
Feb 17, 1998·Neuroscience Letters·F ChenA J Lawrence
Jul 25, 2003·Alcohol·Daniel J Lodge, Andrew J Lawrence
Sep 12, 2006·Addiction Biology·David H OverstreetAndrew J Lawrence
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·M S CowenA J Lawrence
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·F Chen, A J Lawrence
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·M S Cowen, A J Lawrence
Aug 2, 2014·Behavioural Brain Research·Arojit MitraElena Timofeeva
Aug 5, 1998·Brain Research·M S CowenA J Lawrence
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Jennifer Lynn ShortAndrew John Lawrence
Aug 25, 2004·NeuroImage·Raffael KalischDorothee P Auer
Aug 18, 2004·Neuroscience·T Featherby, A J Lawrence
Sep 20, 2006·Neuroscience and Biobehavioral Reviews·David H OverstreetAndrew J Lawrence
Sep 1, 2015·Neuroscience·R BredewoldA H Veenema
Dec 25, 2012·Behavioural Brain Research·Ronak AzizbeigiShamseddin Ahmadi
May 20, 2014·Drug and Alcohol Dependence·P J RyanA J Lawrence
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer Lynn ShortAndrew John Lawrence
Feb 21, 2008·Journal of Neurochemistry·James E SmithCarol C Cunningham
Aug 30, 2014·Behavioural Pharmacology·Thomas R MorrisonRichard H Melloni
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Elvan Djouma, Andrew J Lawrence
Jan 21, 2021·Diagnostics·Maria BeckerAsher Ornoy
Sep 9, 2017·Pharmacology, Biochemistry, and Behavior·Alana Witt HansenRosane Gomez