Apr 5, 2020

Hypergraphs for predicting essential genes using multiprotein complex data

BioRxiv : the Preprint Server for Biology
Florian KlimmG. Reinert

Abstract

Protein-protein interactions are crucial in many biological pathways and facilitate cellular function. Investigating these interactions as a graph of pairwise interactions can help to gain a systemic understanding of cellular processes. It is known, however, that proteins interact with each other not exclusively in pairs but also in polyadic interactions and they can form multiprotein complexes, which are stable interactions between multiple proteins. In this manuscript, we use hypergraphs to investigate multiprotein complex data. We investigate two random null models to test which hypergraph properties occur as a consequence of constraints, such as the size and the number of multiprotein complexes. We find that assortativity, the number of connected components, and clustering differ from the data to these null models. Our main finding is that projecting a hypergraph of polyadic interactions onto a graph of pairwise interactions leads to the identification of different proteins as hubs than the hypergraph. We find in our data set that the hypergraph degree is a more accurate predictor for gene-essentiality than the degree in the pairwise graph. We find that analysing a hypergraph as pairwise graph drastically changes the distri...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Genome
Genes
Trees (plant)
Nucleic Acid Hybridization Procedure
Multilocus Sequence Typing
Genomics
Simulation
Species
Analysis
Lymphatic Tree

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society
L K Hyung, C H Cho
PloS One
Bogumił KamińskiFrançois Théberge
IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society
Taisong JinDacheng Tao
© 2020 Meta ULC. All rights reserved