PMID: 3755450Sep 1, 1986Paper

Distribution of glucagon-like peptide I in canine and feline pancreas and gastrointestinal tract

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
C R Vaillant, P K Lund

Abstract

Recently, a putative hormone, glucagon-like peptide I (GLP I), has been identified in the predicted sequences of the precursors to pancreatic glucagon in human, rat, hamster, and ox. The distribution of GLP I immunoreactivity in canine and feline pancreas and gastrointestinal tract was examined immunohistochemically and was compared with that of two other antigenic determinants of pancreatic pro-glucagon, i.e., glucagon and the NH2 terminus of glicentin. All three determinants occurred in the same population of islet cells in normal pancreas and in pancreas consisting predominantly of islet tissue from dogs with canine pancreatic acinar atrophy. Northern blot analysis of mRNA from the latter tissue, using a rat pre-pro-glucagon complementary DNA probe, revealed a single mRNA species similar in size to the pre-pro-glucagon mRNA detected in fetal rat pancreas. The three antigenic determinants of pancreatic pro-glucagon were co-localized also in intestinal L-cells and in canine gastric A-cells. Canine and feline pancreatic pro-glucagons therefore resemble those identified in other mammals and may also occur in gastrointestinal endocrine cells. Although there is evidence that the GLP I sequence is not liberated from pancreatic pro-...Continue Reading

Citations

Aug 1, 1990·Cell and Tissue Research·I Salazar, C Vaillant
Jun 12, 2013·Domestic Animal Endocrinology·C GilorO Dossin
Mar 26, 2013·The Veterinary Clinics of North America. Small Animal Practice·Claudia E Reusch, Isabelle Padrutt
Jan 10, 2012·Peptides·Jizette V HuntAyman I Sayegh
Aug 28, 2010·International Journal of Peptides·Anna-Sophia WisserPeter Kobelt
Mar 28, 2002·DNA Sequence : the Journal of DNA Sequencing and Mapping·D M Irwin
May 15, 1988·Analytical Biochemistry·M Wilchek, E A Bayer
Oct 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation·H TakahashiH Sasaki
Aug 28, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·M TomanV Svobodová
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·E E DanielT J McDonald

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