Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain

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M S Todtenkopf, Francine M Benes

Abstract

Recent studies have reported an increase in GABAA receptor binding activity in several key corticolimbic regions, including the hippocampal formation, of postmortem schizophrenic brain. Because this change has been postulated to represent a compensatory upregulation of this receptor, the current report has sought to determine whether a decrease of glutamate decarboxylase (GAD), the enzyme responsible for the synthesis of GABA, may also be present in the hippocampus of schizophrenic subjects. A standard immunoperoxidase technique, together with a computer-assisted microscopic analysis, has been employed to evaluate the distribution of the 65 kDalton isoform of GAD (GAD65) in 12 normal controls and 13 schizophrenic subjects matched for age and postmortem interval (PMI). The results show no significant difference in the density of GAD65-immunoreactive (-IR) puncta in contact with pyramidal neurons (PN), nonpyramidal neurons (NP), or neuropil (NPL) in sectors CA1-4 and their various sub-laminae. When the data were considered in relation to neuroleptic exposure, a significant positive correlation between the density of GAD65-IR puncta and drug dose was found on both PNs (r = 0.814, P = 0.002; r = 0.777, P = 0.005, respectively) and ...Continue Reading

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Citations

Mar 17, 2000·Brain Research. Brain Research Reviews·F M Benes
Oct 2, 2003·Brain Research. Developmental Brain Research·Hongxin DongJohn G Csernansky
Aug 3, 2000·Brain Research Bulletin·M S TodtenkopfJ R Stellar
Sep 4, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francine M Benes
Aug 27, 2010·Cerebral Cortex·Carlos Sánchez-Huertas, Beatriz Rico
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Barbara GisabellaFrancine M Benes
Jun 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francine M BenesMartin Minns
Jul 16, 2008·Gene Expression Patterns : GEP·Kate D Meyer, Jill A Morris
Apr 29, 2004·Journal of Neuroscience Research·Stella DrachevaVahram Haroutunian
Feb 3, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H Le-NiculescuA B Niculescu
Apr 25, 2013·CNS Neuroscience & Therapeutics·Bernat KocsisMihaly Hajos
Jul 1, 1998·Biological Psychiatry·F M BenesM S Todtenkopf
May 1, 2012·Biological Psychiatry·Hanna E StevensFlora M Vaccarino
Sep 5, 2006·Biological Psychiatry·Harry PantazopoulosSabina Berretta
Jun 9, 2006·Brain Research Reviews·Schahram Akbarian, Hsien-Sung Huang
Feb 7, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·S Yeap, J H Thakore
Sep 29, 2004·Biochemical Pharmacology·Joseph T Coyle
Feb 5, 2005·Biological Psychiatry·E Fuller TorreyMichael B Knable
Jan 15, 2015·Pharmacology & Therapeutics·William T O'Connor, Sean D O'Shea
Oct 14, 2016·Cerebral Cortex·Sivan SubburajuFrancine M Benes
Apr 29, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott A HeldtKerry J Ressler

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