Distribution of glutathione S-transferase M1, P1 and T1 genotypes in different age-groups of Finns without diagnosed cancer

Cancer Detection and Prevention
Anu VohoAri Hirvonen

Abstract

Xenobiotic metabolizing enzymes (XMEs) are important detoxifiers of hazardous environmental agents, and their polymorphisms may therefore modify the risk of environmentally induced cancers. Consequently, the XME polymorphisms have been extensively studied in this context during recent years. Particular attention has been given to the polymorphisms of glutathione S-transferase (GST) M1, P1 and T1 genes. Previous studies have provided abundant data indicating these polymorphisms as important modifiers of individual susceptibility to cancers of environmental origin. It can be postulated that if the at-risk genotypes of these genes were real risk factors for the environmental cancers, their prevalence would presumably decrease with age in cancer-free part of the population. We tested the hypothesis in a population based group of 2105 Finns (1,051 men, 1,054 women) in five age strata (27, 37, 47, 57 and 67 years of age), all without clinically diagnosed cancer. For GSTM1 genotype, a significant interaction was seen between gender and age among never smokers (p=0.003). Currently smoking men tended to be less likely (OR 0.57, 95% CI 0.31-1.03), and currently smoking women more likely (OR 1.70, 95% CI 0.97-2.97) homozygotes for the GST...Continue Reading

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Citations

Dec 15, 2010·European Journal of Nutrition·Alexandra HorskaMaria Dusinska
Oct 27, 2011·Pharmacogenetics and Genomics·Mari K KukkonenAri Hirvonen
Oct 7, 2011·Environmental Health : a Global Access Science Source·Hans B KetelslegersNicolas A van Larebeke
Feb 19, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L M BullH B El-Serag
Jul 7, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M W GerbaseN Probst-Hensch
Mar 2, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Kazuaki SakaiKazutoshi Nakamura

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