Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain

Neuroscience
C RamponM Jouvet

Abstract

To localize glycinergic cell bodies and fibers in the rat brain, we developed a sensitive immunohistochemical method combining the use of specific glycine antibodies (Campistron G. et al. (1986) Brain Res. 376, 400-405; Wenthold R. J. et al. (1987) Neuroscience 22, 897-912) with the streptavidin-horseradish peroxidase technique and 3,3'-diaminobenzidine.4HCl-nickel intensification. We confirmed the presence of numerous glycine-immunoreactive cell bodies and fibers in the cochlear nuclei, superior olivary complex, nucleus of the trapezoid body, cerebellar cortex, deep cerebellar nuclei and area postrema. For the first time in rats, we described a large to very large number of cell bodies in the medial vestibular ventral part, prepositus hypoglossal, gracile, raphe magnus and sensory trigeminal nuclei. A large number of cells was also observed in the oral and caudal pontine, parvocellular, parvocellular pars alpha, gigantocellular and gigantocellular pars alpha reticular nuclei. In addition, glycine-immunoreactive cells were seen in the ambiguous and subtrigeminal nuclei, the lateral habenula and the subfornical organ. We also provide the first evidence in rats for a very large number of fibers in the trigeminal, facial, ambiguou...Continue Reading

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Citations

Oct 15, 2009·The Cerebellum·Marylka Uusisaari, Thomas Knöpfel
Nov 19, 2003·European Journal of Pharmacology·Daniel S MathonGeert M J Ramakers
Oct 15, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Patrizia VoehringerBoris Ferger
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Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ramalingam VetrivelanJun Lu
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