Distribution of granule cells projecting to focal Purkinje cells in mouse uvula-nodulus

Neuroscience
Neal H Barmack, Vadim Yakhnitsa

Abstract

Mossy and climbing fibers convey a broad array of signals from vestibular end organs to Purkinje cells in the vestibulo-cerebellum. We have shown previously that Purkinje cell simple spikes (SSs) and climbing fiber-evoked complex spikes (CSs) in the mouse uvula-nodulus are arrayed in 400 microm wide sagittal climbing fiber zones corresponding to the rotational axes of the vertical semicircular canals. It is often assumed that mossy fibers modulate a higher frequency of SSs through the intermediary action of granule cells whose parallel fibers course through the Purkinje cell dendritic tree. This assumption is complicated by the diffuse topography of vestibular primary afferent mossy fiber projections to the uvula-nodulus and the dispersion of mossy fiber signals along folial axes by parallel fibers. Here we measure this parallel fiber dispersion. We made microinjections of neurobiotin into the molecular layers of different folia within the mouse vestibulo-cerebellum and measured the distribution of granule cells retrogradely labeled by the injected neurobiotin. Sixty-two percent of labeled granule cells were located outside a 400 microm sagittal zone flanking the injection site. The dispersion of labeled granule cells was appro...Continue Reading

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Feb 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Neal H Barmack, Vadim Yakhnitsa

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Citations

Oct 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nadia L CerminaraRichard Apps
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Neal H Barmack, Vadim Yakhnitsa
Sep 3, 2010·The Cerebellum·Jan VoogdChris I De Zeeuw
May 6, 2016·Frontiers in Computational Neuroscience·Anna CattaniClaudio Canuto
Apr 23, 2020·Frontiers in Neuroinformatics·Hiroshi YamauraTadashi Yamazaki
Feb 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Trace L StayDora E Angelaki

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