PMID: 7581494Jan 1, 1995Paper

Distribution of GSTM1 null genotype in relation to gender, age and smoking status in Japanese lung cancer patients

Pharmacogenetics
M KiharaM Kihara

Abstract

GSTM1 gene deficiency has been shown to occur in approximately half of the populations of various ethnic origins and has been implicated as a factor for elevated risk for lung cancers. However the results have been variable or even conflicting between the studies. In an attempt to explore the reason for such a diversity, we studied the distribution of GSTM1 genotypes in relation to gender, age and smoking status in 447 Japanese lung cancer patients and 469 community controls. We found: (1) that in squamous and small cell carcinomas GSTM1 null genotype distributed markedly more in females than males especially among the patients aged < 70 years (male 57.4%, female 100.0%); (2) that GSTM1 null genotype distributed generally more in patients aged < 70 years (58.3%) than those aged > or = 70 years (50.0%) irrespective of histologies except for small cell carcinoma; and (3) that proportion of GSTM1 null genotype increased dependent on the extent of tobacco smoke exposure in male patients having squamous and small cell carcinomas aged < 70 years, and remained high but independent of the smoking index in adenocarcinoma and unchanged in never- or exsmokers from the control level (48.6%). The present study thus suggests that composition...Continue Reading

Citations

Nov 27, 1999·Molecular Aspects of Medicine·J A Hasler
Oct 14, 2003·Cancer Genetics and Cytogenetics·Hatice PinarbasiErgun Pinarbasi
Sep 21, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E V BelogubovaE N Imyanitov
Aug 24, 2010·Pharmacogenetics and Genomics·Scott M LangevinUNKNOWN Genetic Susceptibility to Environmental Carcinogens group (GSEC)
Sep 28, 2007·Journal of Carcinogenesis·Adalet DemirSeyyit Ibrahim Dincer
Mar 26, 2002·Journal of Occupational and Environmental Medicine·Linda Morris BrownJoseph F Fraumeni
Jan 6, 2010·Molecular and Cellular Biochemistry·Rosa Estela Caseira CabralMaria da Gloria Costa Carvalho
Jul 16, 2008·Clinical Lung Cancer·Mary E ReidChristine B Ambrosone
May 7, 2016·Genetic Testing and Molecular Biomarkers·Pengfei HeQing Liu
Apr 17, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·R C SobtiSara Raimondi
Jul 1, 1997·Critical Reviews in Toxicology·S D SpivackL S Kaminsky

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