Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in Pakistan.

BMC Gastroenterology
Javed YakoobMuhammad Islam

Abstract

Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU). H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out. Two hundred and twenty-four patients were included, 141 (63%) were males with a mean age of 45 +/- 16, range 16-83 years. The virulence marker cagA was associated with GU in 20(63%) (p = 0.04), DU in 23(72%) (p = 0.003) and GC in 29(73%) (p = 0.001) compared to NUD in 51(42%). VacA s1am1 was associated with GU in 23(72%) (p = 0.001), DU in 17(53%) (p < 0.001) and GC in 23(58%) (p = 0.003) compared to NUD in 38(32%) while vacA s1bm1 was also associated with GU in 9(28%) (p = 0.001), DU in 12(37%) (p < 0.001) and GC 11(28%) (p < 0.001) compared to NUD in 13(11%), respectively. The diagnoses of GU in 21(66%), DU in 16(50%), GC in 20(50%) and ...Continue Reading

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Citations

Sep 21, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Javed YakoobSafia Awan
May 22, 2013·ISRN Gastroenterology·Tamer EssawiMohammad A Farraj
Dec 5, 2014·Clinical and Experimental Medicine·Batool MottaghiMohammad Hossein Somi
Oct 31, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Javed YakoobWasim Jafri
Sep 7, 2012·Diagnostic Microbiology and Infectious Disease·Daniel YordanovIvan Mitov
Dec 10, 2015·Journal of Gastroenterology and Hepatology·Esmat AbdiBahareh Safarnejad
Feb 11, 2012·Journal of Korean Medical Science·Mohammed Ali M Marie
May 15, 2013·Journal of Neurogastroenterology and Motility·Sung Eun KimHyun Chae Jung
Feb 4, 2016·Arquivos De Gastroenterologia·Igor Dias Ferreira VinagreLuisa Caricio Martins
Jul 27, 2014·Molecular Biology Reports·Bei-Bei ZhangDong-Lin Bian
Mar 24, 2018·Indian Journal of Pathology & Microbiology·Lavanya JeyamaniMukundan Swaminathan

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Datasets Mentioned

BETA
ACN25132
ACN25130
ACN25131
U05676
ACN25133

Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

BLAST
Macrogen
SPSS

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