Distribution of hemolytic complement in the normal cornea

Archives of Ophthalmology
B J Mondino, K J Brady

Abstract

Hemolytic activities in the central cornea were compared with hemolytic activities in the peripheral cornea for each of the following complement components: C1, C4, C2, C3, C5, C6, and C7. For all seven complement components studied, hemolytic activities in the peripheral cornea were higher than hemolytic activities in the central cornea, and the differences were statistically significant. The most striking difference was for C1, which had a ratio of mean hemolytic activity in the peripheral cornea to that in the central cornea of almost 5:1. For the other six complement components, the ratio of the mean hemolytic activity in the peripheral cornea to that in the central cornea was approximately 1.2:1. This distribution of complement activity in the cornea suggests that the major source of complement components is the limbal vessels and that complement components diffuse from the limbus to the central cornea.

Citations

Feb 27, 2008·Seminars in Immunopathology·Nalini S BoraPuran S Bora
Jun 2, 2012·Clinical Ophthalmology·Ayse Yagci
May 26, 1999·Survey of Ophthalmology·E M Messmer, C S Foster
Aug 4, 2007·International Ophthalmology·Eva-Marie Chong, M Reza Dana
Jan 1, 1989·Critical Reviews in Microbiology·S DarougarR M Woodland
Aug 4, 2011·Journal of Invertebrate Pathology·Minna U KaikkonenKari J Airenne
Sep 5, 2007·Molecular Immunology·Purushottam JhaNalini S Bora
Nov 25, 2003·Eye·E K Akpek, J D Gottsch
Feb 1, 1991·Australian and New Zealand Journal of Ophthalmology·P R Badenoch
Jan 1, 1994·Eye·L Missotten
Mar 23, 2001·Current Eye Research·E CocuzziE M Medof
Oct 17, 2003·Current Eye Research·Catherine BlondinChristophe Baudouin
Aug 1, 1991·Current Eye Research·M S Suttorp-SchultenA Kijlstra
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L R HallE Pearlman
Jan 15, 2021·Translational Vision Science & Technology·Sina SharifiJames Chodosh
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·L Bielory

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.