Distribution of HLA class I and II genes in ankylosing spondylitis patients from Morocco

Pathologie-biologie
O AtoufM Essakalli

Abstract

In Morocco, the patients affected by ankylosing spondylitis (AS) presents a high frequency of coxitis. Our study reports, for the first time, the polymorphism of Human Leukocyte Antigen (HLA) class I and class II molecules in the Moroccan patients. Forty-six patients diagnosed with an AS and coxitis were compared to a group of 183 healthy controls matched by age, sex and ethnic origin. The HLA typing was performed using microlymphocytotoxicity for the class I (-A, -B) and PCR-SSP for the class II (-DR, -DQ). We found a significant increase of the HLA-B27 antigen frequency (P<0.0001, RR=20.9) in AS patients (29.3%) compared to the controls (3.2%) and a significant decrease in the frequency of HLA-B12 and HLA-B18 antigens. Examination of HLA class II distribution shows a significant increase of the HLA-DRB1*11 allele frequency in patients (P<0.0001). Concerning HLA-DQB1* alleles, no significant difference between patients and controls was appreciable. The HLA-B27 antigen is involved in the predisposition to the AS with coxitis in the Moroccan population. However, the low frequency observed in our population suggests the existence of other genetic and/or environmental factors. Other HLA genes seem to confer a predisposing effect (...Continue Reading

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Citations

Nov 26, 2015·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·C BrickM Essakalli
May 9, 2015·Molecular and Cellular Probes·Chehrazade BrickMalika Essakalli
Jul 4, 2012·The Journal of Rheumatology·Khader N MustafaMuhammad Asim Khan
Jan 4, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiang LiYan Wang

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