PMID: 9168851Jan 1, 1997Paper

Distribution of IgE and IgG antibody levels against house dust mites in schoolchildren, and their relation with asthma

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Masanao ShibasakiH Takita

Abstract

Although asthmatic patients are known to have increased levels of IgG antibody against house dust mite (HDM), it is not clear whether or not the presence of HDM-specific IgG antibody is associated with the etiological mechanism of asthma. To address this problem, we evaluated the relationship between HDM-specific IgG antibody levels and incidence of asthma in a general pediatric population. IgE and IgG antibody levels against Dermatophagoides farinae (Df) were examined by RAST and ELISA in a total of 722 randomly selected schoolchildren including 26 subjects with asthma, and the relative prevalence rates of asthma in this population were evaluated in relation to both Df-specific IgE and IgG levels. The incidence of asthma correlated not only with levels of Df-specific IgE, but also with those of Df-specific IgG. There was a significant correlation between Df-specific IgE and IgG levels both in the total population and in the asthmatic children. Because IgG and IgE responses occurred in parallel in this population, the clinical significance of HDM-specific IgG anti-body remains unclear. However, our findings have suggested that clinical expression of asthma in children is primarily dependent on their capacity to mount a immune r...Continue Reading

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Citations

Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Emiko NoguchiTadao Arinami
Apr 2, 2009·BMC Research Notes·Yoshiko ImadaEmiko Noguchi
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NoguchiT Arinami
Jun 23, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Metin AydoganIsil Barlan
Sep 1, 2006·Expert Review of Clinical Immunology·Osamu KaminumaAkio Mori
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·E Noguchi, T Arinami

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