Distribution of immunoreactive peptide B in the rat brain

Biochemical and Biophysical Research Communications
I Lindberg, L White

Abstract

Peptide B represents one of the most highly conserved sequences in proenkephalin. To investigate the potential presence of this peptide in the mammalian nervous system, an antiserum raised to this peptide was used to measure the distribution and molecular weight forms of immunoreactive Peptide B in the rat brain. Peptide B-immunoreactivity (ir) was found to be most concentrated in the hypothalamus and the striatum, with lower concentrations in the midbrain and medulla-pons. Characterization of Peptide B-ir by gel filtration demonstrated that the major immunoreactive peak in the hypothalamus corresponded to a peptide with the approximate molecular weight of Peptide B. The major immunoreactive peptide exhibited a retention time on HPLC indicative of a peptide slightly more hydrophilic than bovine Peptide B. The results suggest that proenkephalin in rat brain can be processed to peptides related to bovine Peptide B.

References

Aug 16, 1984·Biochemical and Biophysical Research Communications·M SondersE Weber
Jan 1, 1983·Life Sciences·C W PittiusA Herz

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Citations

Jun 7, 2015·Peptides·Jayaram Lakshmaiah Narayana, Jyh-Yih Chen
Sep 1, 1992·The Journal of Comparative Neurology·M S AiraksinenP Panula
Nov 24, 2001·The Journal of Biological Chemistry·Yolanda FortenberryIris Lindberg
Dec 5, 1998·The Journal of Biological Chemistry·B KiefferM H Metz-Boutigue
Aug 26, 1998·The Journal of Biological Chemistry·K JohanningI Lindberg

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