PMID: 804450May 1, 1975

Distribution of indigenous bacteria in the digestive tract of conventional and gnotobiotic rats

Infection and Immunity
M MorotomiM Mutai

Abstract

The localization and population levels of the indigenous bacterial flora of conventional rats were investigated by cultural and histological techniques. Lactobacilli predominate in the stomach and upper part of the small intestine and associate with keratinized cells of the nonglandular portion of stomach. Mixtures of varying complexity of pure cultures of indigenous bacteria were inoculated into germfree rats. The distribution of these bacteria was examined to investigate the effect of lactobacilli in controlling the composition of other bacterial species in each portion of the digestive tract. In the stomach and the upper part of the small intestine, lactobacilli controlled the population levels of other bacterial species. In the lower part of the small intestine, not only lactobacilli but also the anaerobes which colonized the large bowel influenced the population levels of other bacterial types. Staphylococci isolated from a conventional rat colonized specifically the keratinized cells of the nonsecreting epithelium of the stomach when the rats were free from lactobacilli. This colonization was not observed after inoculation of lactobacilli into the rats.

Citations

Dec 10, 2003·Canadian Journal of Microbiology·S P J BrooksM L Kalmokoff
Oct 19, 2010·The Journal of Veterinary Medical Science·Yuh YokooHiroshi Kitagawa
Mar 7, 2007·The Journal of Veterinary Medical Science·Keigi ChinHiroshi Kitagawa
Apr 10, 2010·The Journal of Veterinary Medical Science·Kenkichi YamamotoHiroshi Kitagawa
Jan 1, 1981·Microbiology and Immunology·K TohyamaM Mutai
Oct 27, 2015·Nature Reviews. Microbiology·Gregory P DonaldsonSarkis K Mazmanian
Mar 10, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Wenping HuNing Li
Jan 1, 1981·Microbiology and Immunology·T WatanabeM Mutai
Feb 7, 2001·The American Journal of Clinical Nutrition·C DunneJ K Collins

Related Concepts

Anaerobiosis
Bacteriological Techniques
Bacteroides
Cecum
Gastrointestinal System
Alkalescens-Dispar Group
Gnotobiotics
Intestines, Small
Lactobacillus
Genus staphylococcus

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