Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species

New Microbes and New Infections
Julien BadorLucie Amoureux

Abstract

Achromobacter spp. are emerging respiratory pathogens in cystic fibrosis patients. Since 2013 the genus Achromobacter includes 15 species for which innate antibiotic resistance is unknown. Previously the AxyXY-OprZ efflux system has been described to confer aminoglycoside (AG) resistance in A. xylosoxidans. Nevertheless, some Achromobacter spp. strains are susceptible to AG. This study including 49 Achromobacter isolates reveals that AG resistance is correlated with different Achromobacter spp. It is noteworthy that the axyXY-oprZ operon is detected only in AG-resistant species, including the most frequently encountered in cystic fibrosis patients: A. xylosoxidans, A. ruhlandii, A. dolens and A. insuavis.

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Citations

Apr 7, 2017·Genome Biology and Evolution·Julie JeukensRoger C Levesque
Jun 15, 2017·Frontiers in Cellular and Infection Microbiology·Brankica FilipicBranko Jovcic
Aug 21, 2020·Antimicrobial Agents and Chemotherapy·Burcu IslerDavid L Paterson
Apr 14, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T GarrigosUNKNOWN Collaborators
May 21, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lucie AmoureuxUNKNOWN MucoMicrobes group
Aug 7, 2021·Antibiotics·Viola Camilla ScoffoneSilvia Buroni

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Methods Mentioned

BETA
PCR

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