Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways

American Journal of Respiratory Cell and Molecular Biology
A WeinackerD Sheppard

Abstract

We have previously identified two integrins, alpha 9 beta 1 and alpha v beta 6, from guinea pig airway epithelium. The extracellular matrix protein tenascin is a ligand for both of these receptors, and fibronectin is also a ligand for alpha v beta 6. In the present study, we used immunohistochemistry to examine the expression and spatial distribution of the alpha 9 subunit, alpha v beta 6, tenascin, and fibronectin in the proximal airways of 10 normal nonsmoking subjects and eight patients undergoing lung resection for cancer. We also performed the same analyses on sections of peripheral lung obtained from an additional seven subjects undergoing lung resection. alpha 9 was highly expressed throughout the airway epithelium (but not on alveolar epithelium) irrespective of clinical status. In contrast, alpha v beta 6 was expressed on proximal airway epithelial cells in four of eight smokers undergoing lung resection, but in none of the normal subjects and none of the distal airways examined. On bronchial epithelial cells cultured from resected airways, alpha v beta 6 was highly expressed on cells grown from patients who did not appear to express the receptor in vivo, as well as from subjects who did, suggesting that some component...Continue Reading

Citations

Jun 12, 1999·The Journal of Pathology·D J HarringtonH J Mardon
Dec 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A WangD Sheppard
Aug 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Sheppard
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·A LaitinenL A Laitinen
Nov 18, 1998·The Journal of Allergy and Clinical Immunology·M HoshinoS Isogai
Nov 10, 2000·Advanced Drug Delivery Reviews·R J Parkes, S L Hart
Jan 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A J Perumpanani, H M Byrne
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·A LaitinenL A Laitinen
May 2, 1998·American Journal of Respiratory Cell and Molecular Biology·S Potter-PerigoT N Wight
Sep 9, 1998·American Journal of Respiratory Cell and Molecular Biology·A J JabbourD L Luchtel
Sep 9, 1998·American Journal of Respiratory Cell and Molecular Biology·D Sheppard
Apr 1, 2006·American Journal of Respiratory Cell and Molecular Biology·Claus NeurohrDean Sheppard
Sep 26, 2013·The Journal of Oral Implantology·Pablo Galindo-MorenoFrancisco O'Valle
Jan 13, 2009·Pulmonary Pharmacology & Therapeutics·Janette K BurgessJane Ward
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Zeljko VujaskovicDavid M Brizel
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Liguang ChenZeljko Vujaskovic
Oct 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Minxiao YiXianglin Yuan
Jan 26, 2013·PloS One·Lamei ChengQi Yan
Mar 28, 2006·Journal of Immunological Methods·Pulak TripathiDavid A Hildeman
Mar 11, 2005·Advanced Drug Delivery Reviews·Zhi-Li XuTakao Hayakawa
Feb 28, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Nadia Rucci, Anna Teti
Jul 27, 2005·Journal of Dermatological Science·Kaoru OgawaChisei Ra
Oct 6, 1997·Human Pathology·G K KoukoulisV E Gould
Oct 23, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A V LjubimovM C Kenney
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L A MillerD M Hyde
Jul 13, 2004·The Journal of Biological Chemistry·Mousumi MajumdarYoshikazu Takada
Jul 14, 1998·FEBS Letters·H SchneiderC Coutelle
Feb 13, 2001·FEBS Letters·P J JostH Schneider
Sep 26, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Theresa M McDevittPhilip L Ballard
Apr 7, 2005·Journal of Cataract and Refractive Surgery·Ulrike SponerChristian Skorpik
Apr 26, 2000·British Journal of Cancer·S HamidiH Larjava
Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·K ArihiroY Yokosaki
Jun 10, 2016·Journal of Virology·Edward YangStefan L Oliver
Jul 5, 2003·Physiological Reviews·Dean Sheppard

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