Distribution of intrathecal catheter positions in rat

Acta Anaesthesiologica Scandinavica
F AsatoT Gordh

Abstract

Although drug administration through an intrathecal catheter is widely used in the study of spinal pharmacology, the catheter positions in transverse plane that may cause a limited spread of a solution remain unclear. In the first step to clarify this issue, the distribution of the intrathecal catheter position was investigated in rats. A polyethylene catheter (PE-10) was inserted intrathecally 8.5 cm through the atlanto-occipital membrane, aiming the tip of the catheter to the dorsal surface of the spinal cord. Three or four weeks after the implantation of the catheter, 83 rats were transcardiacally perfused with fixative solution. The catheter positions were investigated longitudinally and transversely by cutting the spinal cord segmentally through the intervertebral disk at different spinal levels. Seventeen rats were excluded from further data analysis. Transversely, catheters were located in the left lateral subarachnoid space in 23 rats (35%), in the right lateral in 15 (23%), in the dorsal in 22 (33%), and in the ventral in 6 (9%). Longitudinally, catheter position was significantly higher in the ventral group (median, T9) than that in the dorsal group (T11/12) (P<0.01). Chronic intrathecal catheters were variously locat...Continue Reading

References

Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·B DibA E Panerai
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·B C WangH Turndorf
Mar 1, 1985·British Journal of Anaesthesia·S B Akerman
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·B Dib
Apr 1, 1984·British Journal of Anaesthesia·M BaharM D Vickers
Sep 1, 1981·Physiology & Behavior·R M LoPachinT L Yaksh
Apr 1, 1996·Journal of Neuroscience Methods·R V StørksonK Hole
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

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Citations

Sep 21, 2001·Journal of Neuroscience Methods·L Jasmin, P T Ohara
Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
Jan 23, 2003·Anesthesia and Analgesia·Ildiko DobosGyongyi Horvath
Jun 8, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Liming ChenLei Pei
Apr 28, 2005·European Journal of Anaesthesiology·T J LugerI H Lorenz
Aug 22, 2021·Journal of Neuroscience Methods·Azim Arman, Mark R Hutchinson

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