PMID: 9187335May 9, 1997Paper

Distribution of ionotropic glutamate receptor subunit immunoreactivity in the suprachiasmatic nucleus and intergeniculate leaflet of the hamster

Brain Research
J A StampK Semba

Abstract

Glutamate is thought to mediate the effects of light on the circadian pacemaker contained in the suprachiasmatic nucleus. Glutamate can reset this pacemaker both in vivo and in vitro while glutamate antagonists can reduce photically induced phase shifts in activity rhythms and c-fos expression in the suprachiasmatic nucleus. Most behavioural and gene expression experiments investigating circadian rhythms use hamsters, but the majority of the anatomical data on the presence and distribution of selected glutamate receptor subunits in the suprachiasmatic nucleus has been collected from rat. In the present study, we examined the distribution of ionotropic glutamate receptor subunits in the hamster suprachiasmatic nucleus using mono- and polyclonal antibodies directed against these subunits. In addition, we examined the distribution of immunostaining for these subunits in a second structure of the mammalian circadian system, the intergeniculate leaflet of the thalamus since it also is thought to receive glutamatergic input from the retina and is important in the entrainment of circadian rhythms. The results indicated that all of the subunits investigated (GluR1, GluR2/3, GluR4, GluR5/6/7, and NMDAR1) were present in the suprachiasma...Continue Reading

Citations

Mar 13, 2020·Physiological Reviews·Jenna R M HarveyAndrea L Meredith
Oct 16, 2002·The Journal of Comparative Neurology·Maryvonne Warembourg, Daniele Leroy
Jun 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allison BragerJ David Glass
Aug 7, 2002·Journal of Neurophysiology·Stephan MichelChristopher S Colwell
Dec 13, 2006·The European Journal of Neuroscience·T BlasiakM H Lewandowski
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen

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