Distribution of IRAG and cGKI-isoforms in murine tissues

FEBS Letters
Angela GeiselhöringerJ Schlossmann

Abstract

cGMP kinase I (cGKI) signaling modulates multiple physiological processes including smooth muscle relaxation. The expression of cGKI and its substrate IRAG (Inositol 1,4,5-trisphosphate receptor associated cGMP kinase substrate) was studied. IRAG and cGKI were colocalized in the smooth muscle of aorta and colon. IRAG was present in the thalamus and in most of the myenteric plexus in the absence of cGKI. Coexpression of IRAG and cGKIbeta or cGKIalpha in COS-7 cells revealed that IRAG recruits cGKIbeta but not cGKIalpha to the endoplasmic reticulum. These results suggest that IRAG may be involved in cGKI-dependent and -independent pathways.

References

Sep 1, 1992·European Journal of Biochemistry·A KeilbachF Hofmann
Nov 17, 1994·Nature·A P Somlyo, A V Somlyo
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P RuthF Hofmann
Jun 26, 1998·The EMBO Journal·A PfeiferF Hofmann
Feb 5, 1999·Reviews of Physiology, Biochemistry and Pharmacology·A PfeiferF Hofmann
Nov 24, 1999·Journal of Chemical Neuroanatomy·A E El-HusseiniS R Vincent
Oct 31, 2000·Circulation Research·M SausbierF Hofmann
Dec 12, 2001·Neuroscience·J de VenteM Palkovits

❮ Previous
Next ❯

Citations

Jan 1, 2008·The AFCS-nature Molecule Pages·Sarabeth M GrahamPeter Koulen
Nov 26, 2010·The Journal of Biological Chemistry·Yuan-Wei Zhang, Gary Rudnick
Jul 9, 2013·Cardiovascular Research·Florian LogaJörg W Wegener
Apr 19, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert LukowskiRobert Feil
Jan 19, 2010·Cardiovascular Research·Matthias DeschJens Schlossmann
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Robert LukowskiFranz Hofmann
Sep 29, 2011·Cellular and Molecular Life Sciences : CMLS·Manuel MorgadoIgnacio Verde
Jan 20, 2011·Platelets·Elisabeth SchinnerJens Schlossmann
Feb 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Seonil KimEdward B Ziff
Jun 14, 2013·Kidney International·Elisabeth SchinnerJens Schlossmann
Jan 12, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Janica C Wong, Ronald R Fiscus
Oct 27, 2009·Progress in Neurobiology·Steven R Vincent
Oct 16, 2004·The EMBO Journal·Angela GeiselhöringerJens Schlossmann
Jan 22, 2009·The FEBS Journal·Beate SpiessbergerFranz Hofmann
Jul 1, 2008·The European Journal of Neuroscience·John Garthwaite
May 12, 2010·Journal of Neurochemistry·Anne-Marie DucheminMaria Hadjiconstantinou
Nov 1, 2005·Cancer Letters·Yali HouDarren Browning
Sep 13, 2005·Brain Research. Developmental Brain Research·Galina P DemyanenkoPatricia F Maness
Sep 15, 2011·European Journal of Pharmacology·Claudia ErtlJörg W Wegener
May 24, 2011·Protein Expression and Purification·Saurabh AggarwalStephen M Black
Aug 4, 2015·Frontiers in Pharmacology·Oleksandra Prysyazhna, Philip Eaton
May 17, 2005·Drug Discovery Today·Jens Schlossmann, Franz Hofmann
Aug 26, 2014·Biochemical and Biophysical Research Communications·Veronika LeissRobert Lukowski
Oct 28, 2010·Diabetes·Veronika LeissRobert Lukowski
Apr 28, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Zheng LiuLing Zhang
Apr 13, 2018·International Journal of Molecular Sciences·Andrea SchrammJens Schlossmann
Jun 23, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Beatrice B YaroslavskiyHarry C Blair
Nov 17, 2004·The Journal of Biological Chemistry·Franz Hofmann
Dec 24, 2005·Physiological Reviews·F HofmannJ Schlossmann
Feb 1, 2006·The Journal of Biological Chemistry·Eva N Christensen, Michael E Mendelsohn
Apr 7, 2005·Reviews in the Neurosciences·Robert FeilThomas Kleppisch
Jul 15, 2015·The Journal of Pharmacology and Experimental Therapeutics·Julia StraubingerRobert Lukowski
Apr 10, 2015·American Journal of Physiology. Cell Physiology·Shin KatoJesse D Roberts
May 16, 2015·PloS One·Stefanie WolfertstetterJens Schlossmann
Nov 21, 2019·Biological Chemistry·Franz Hofmann
Jan 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anurag Kumar SinghFranz Hofmann
Jul 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Subhankar DasKailash N Pandey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.