Distribution of killer cell immunoglobulin-like receptor (KIR) genes in a large, multi-centre cohort of Chinese donors.

Annals of Human Biology
Min HeMing Jiang

Abstract

The killer cell immunoglobulin-like receptor (KIR), which mediates the killing function of NK cells, is an attractive candidate for adoptive cellular therapy. The ethnic distribution for China provides a unique opportunity to investigate KIR gene distribution. The aim of this study was to explore the relationship between population history and the rapidly evolving KIR genetic diversity. 8050 Chinese donors from 184 hospitals were included to analyse frequency, haplotype, and B-content data of 16 KIR genes, by PCR-SSP for KIR genotyping. KIR gene carrier frequencies were found similar to those observed in other studies on Han, but different from Thais, Japanese, Africans, and populations of West Eurasian ancestry. High-frequency KIR genotype profiles found in the present population were consistent with other studies on Han populations but different from those conducted on other cohorts. The majority of our cohort carried group A KIR gene motifs. Additionally, populations with similar geographic locations in China were shown clustered together, while Hainan and Xinjiang provinces were slightly separated from these. The distribution of KIR genes varies by geographic region, and different ethnic groups may be a confounding factor o...Continue Reading

References

Aug 22, 2001·Immunological Reviews·J TrowsdaleM J Wilson
Feb 8, 2005·Human Immunology·Dong Hee WhangMyoung Hee Park
Dec 24, 2009·Immunology·Derek Middleton, Faviel Gonzelez
Dec 25, 2009·Methods in Molecular Biology·Smita KulkarniMary Carrington
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Annettee NakimuliAshley Moffett
Aug 4, 2016·American Journal of Human Genetics·Paul J NormanPeter Parham
Jun 6, 2017·Frontiers in Immunology·Bercelin ManiangouKatia Gagne
May 8, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Suraksha Agrawal, Swayam Prakash

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