PMID: 7018170Jan 1, 1981Paper

Distribution of lactoferrin in human fetal tissues

Acta paediatrica Scandinavica
S ReitamoM Adinolfi

Abstract

We used an immunoperoxidase method to study the distribution of lactoferrin in seven human fetuses from 11 to 21 weeks of age. Lactoferrin was found in mononuclear cells, presumably granulocytes, in various organs from thirteen weeks of gestation onwards. In addition to the liver, spleen, lung and thymus, lactoferrin-positive mononuclear cells were also found close to vessel walls in human pancreas in fetuses more than 20 weeks old. This finding might suggest that there is significant granulopoiesis in the pancreas at this stage of maturation. In addition to the mononuclear cells, lactoferrin could be found in Hassal's corpuscles of the thymus from 13 weeks and in glandular cells of the tongue from 20 weeks onwards. The present results are in good agreement with the maturation of humoral and cellular acquired immunity and the onset of synthesis of lysozyme and interferon.

References

Apr 1, 1978·Journal of Clinical Pathology·D Y Mason, C R Taylor
Jan 1, 1977·Biology of the Neonate·M KlockarsM Adinolfi
Sep 1, 1969·The Journal of Experimental Medicine·P L MassonE Schonne
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Jan 1, 1980·Histochemistry·S ReitamoM Segerberg-Konttinen

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