Distribution of laminins in the developing human eye

Investigative Ophthalmology & Visual Science
Berit ByströmFatima Pedrosa-Domellöf

Abstract

To examine the distribution of laminin (Ln) chains in basement membranes (BMs) of the human cornea, lens, and retina in fetal development. Ten fetal eyes (9-20 weeks of gestation [wg]) were serially sectioned and treated with specific antibodies against the Ln-alpha1, -alpha2, -alpha3, -alpha4, -alpha5, -beta1, -beta2, -beta3, and -gamma1 chains. The BM of the corneal epithelium was reactive for Ln-alpha3, -alpha5, -beta1, and beta3 chains through all ages, whereas the Ln-alpha1 chain was present at 9 to 12 wg and the Ln-alpha4 chain from 10 wg. The Descemet's membrane (DM) was labeled with the Ln-alpha1 and -alpha4 chains at 10 to 17 wg, the Ln-alpha5 chain from 10 wg, the Ln-beta1 chain at 11 to 17 wg, and the Ln-beta3 chain from 17 wg. The Ln-alpha1, alpha5, -beta1, and -beta2 chains were present in the lens capsule and the internal limiting membrane (ILM) through all ages. The Bruch's membrane (BrM) was immunoreactive for the Ln-alpha3, alpha4, -alpha5, -beta1, and -beta2 chains through all ages, whereas the Ln-alpha1 chain was absent from 20 wg onward. The Ln-alpha2 chain was not detected in the eye, but it was present in the extraocular muscles. BMs play an important role during morphogenesis, in that they influence cell ...Continue Reading

Citations

Dec 25, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E AbariA M Joussen
May 12, 2007·Histochemistry and Cell Biology·Berit ByströmFatima Pedrosa Domellöf
Feb 19, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hyun Jin ChoiHae Il Cheong
Jun 17, 2010·Journal of Molecular Histology·Matthias RoedigerNikolaus Gersdorff
Jun 6, 2009·Journal of Molecular Neuroscience : MN·Matthew M HarperDonald S Sakaguchi
Feb 15, 2014·TheScientificWorldJournal·Mallika PathaniaMelinda K Duncan
Aug 4, 2009·Journal of Pediatric Ophthalmology and Strabismus·Taylor SawyerSherry Loo
Sep 9, 2008·Experimental Eye Research·Brian P Danysh, Melinda K Duncan
Aug 2, 2008·American Journal of Ophthalmology·Cecilie BredrupIsabelle Russell-Eggitt
Dec 1, 2006·Seminars in Cell & Developmental Biology·Elizabeth D Wederell, Robb U de Iongh
Mar 12, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Linnéa TaylorFredrik Ghosh
Nov 17, 2012·Cell Adhesion & Migration·Malia M Edwards, Olivier Lefebvre
Mar 31, 2015·Experimental Eye Research·Sayon RoyDongjoon Kim
Sep 16, 2016·Omics : a Journal of Integrative Biology·Krishna R MurthyT S Keshava Prasad
Jun 12, 2018·PloS One·André VicenteFátima Pedrosa Domellöf
Apr 6, 2013·Anatomy & Cell Biology·Fumio HosakaHiroshi Ohguro
Dec 28, 2018·Ophthalmic Genetics·Filomena NapolitanoSimone Sampaolo
Mar 31, 2017·Nature Communications·Natalie A AfshariSudha K Iyengar
Nov 28, 2012·Advanced Healthcare Materials·David W GreenSamuel J K Abraham
Feb 24, 2019·Stem Cell Research & Therapy·Mingjun TangJian Ge
Aug 16, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Arwin ShresthaKristan S Worthington
Jul 6, 2010·Current Eye Research·Zhibin YaoJinsong Zhang
Aug 12, 2018·Investigative Ophthalmology & Visual Science·Valentina BarreraKevin J Hamill
Nov 6, 2020·Investigative Ophthalmology & Visual Science·Deepti SinghLawrence J Rizzolo
Nov 25, 2020·Ophthalmic Surgery, Lasers & Imaging Retina·Abdulaziz AlTaisanSulaiman M Alsulaiman
Jan 1, 2021·Matrix Biology : Journal of the International Society for Matrix Biology·JodiRae DeDreuA Sue Menko
Dec 29, 2020·Development·Michelle O'Hara-Wright, Anai Gonzalez-Cordero
Jul 27, 2021·Development·Michelle O'Hara-Wright, Anai Gonzalez-Cordero
Aug 31, 2021·Frontiers in Genetics·Liam ShawKevin J Hamill

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