Distribution of lutein and zeaxanthin stereoisomers in the human retina

Experimental Eye Research
Richard A BoneW Wang

Abstract

The distribution of macular pigment stereoisomers in the human retina has been mapped and a pathway to account for the presence of the non-dietary carotenoid, meso-zeaxanthin, is proposed. Adult neural retinas were cut into three concentric areas centered on the fovea, and the extracted carotenoids were analysed and purified by high-performance liquid chromatography. The dicarbamate or dibenzoate derivatives of the collected zeaxanthin fractions for each tissue sample were further analysed by HPLC to determine their stereoisomer composition. Whole retinas from infant eyes were similarly analysed. The results show that, relative to zeaxanthin, the concentration of lutein in the adult neural retina increases with radial distance from the fovea while that of meso-zeaxanthin decreases. Infant retinas were found to have more lutein and less meso-zeaxanthin, relative to zeaxanthin, than adult retinas. Small quantities of (3S, 3'S)-zeaxanthin were also found in the adult retina, particularly in the macula. It is proposed that lutein and zeaxanthin are transported into an individual's retina in the same proportions found in his or her blood serum. Some of the lutein is then converted into meso-zeaxanthin, primarily in the macula, by a ...Continue Reading

Citations

Apr 14, 2010·Archives of Ophthalmology·Eliot L BersonErnst J Schaefer
Sep 30, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Simon Paul RothenbuehlerSebastian Wolf
Dec 12, 2012·The British Journal of Nutrition·Béatrice GleizePatrick Borel
Dec 6, 2012·The British Journal of Nutrition·Katherine A MeagherJohn M Nolan
Oct 21, 2010·Expert Reviews in Molecular Medicine·Sam Khandhadia, Andrew Lotery
May 25, 2013·Eye·J M NolanS Beatty
Sep 1, 2000·Asia Pacific Journal of Clinical Nutrition·I E Dreosti
Sep 30, 2003·The British Journal of Nutrition·F GranadoI Blanco
Aug 23, 2006·The British Journal of Nutrition·Myriam RichelleGary Williamson
Oct 30, 2001·The Proceedings of the Nutrition Society·V C JewellD I Thurnham
Feb 24, 2009·Critical Reviews in Food Science and Nutrition·Shannon CarpentierMiyoung Suh
Dec 28, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·L ZhouK W Lam
Apr 28, 2005·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Hannah Bartlett, Frank Eperjesi
May 2, 2007·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·R E HoggR S Anderson
Jun 11, 2002·Annual Review of Nutrition·Kyung-Jin Yeum, Robert M Russell
May 30, 2013·Investigative Ophthalmology & Visual Science·Eric K ChinSusanna S Park
Jul 11, 2013·Investigative Ophthalmology & Visual Science·Bradley S HenriksenPaul S Bernstein
Jul 12, 2012·Nutritional Neuroscience·Rohini VishwanathanElizabeth J Johnson
May 15, 2007·Nutrition & Metabolism·Richard A BoneFrancesca Alvarez-Calderon
Jan 21, 2010·Journal of Nutritional Science and Vitaminology·Sayaka TakedaChizuko Maruyama
Jan 1, 2010·Journal of Nutritional Science and Vitaminology·Thirumurthy VelpandianSupriyo Ghose
Apr 11, 2013·Nutrients·El-Sayed M Abdel-AalRashida Ali
Sep 8, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Binxing LiPaul S Bernstein
Aug 15, 2012·Journal of Dietary Supplements·Ranjita Shegokar, Khalil Mitri
Jan 24, 2015·Journal of Dietary Supplements·Catherine Ulbricht
Nov 14, 2015·Foods·John W ErdmanMartha Neuringer
Mar 15, 2005·Current Eye Research·Ruth Hogg, Usha Chakravarthy
Dec 27, 2015·Fitoterapia·Ramar ManikandanSeyed Mohammad Nabavi
Aug 30, 2003·Photochemistry and Photobiology·Helena H BillstenTomás Polívka
Feb 18, 2016·Journal of Ophthalmology·James A Edwards
Jun 2, 2012·Experimental Eye Research·John M NolanStephen Beatty
Jun 7, 2002·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Werner GellermannPaul S Bernstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.