Oct 1, 1994

Distribution of M cells in the canine ventricle

Journal of Cardiovascular Electrophysiology
S SicouriC Antzelevitch


M cells and transitional cells residing in the deep structures of the ventricular free walls are distinguished by the ability of their action potentials to prolong disproportionately to those of other ventricular cells at relatively slow rates. This feature of the M cell due, at least in part, to a smaller contribution of the slowly activating component of the delayed rectifier current (IKs) is thought to contribute to the unique pharmacologic responsiveness of M cells, making them the primary targets in ventricular myocardium for agents that cause action potential prolongation and induce early and delayed afterdepolarizations and triggered activity. Previous studies dealt exclusively with the characteristics and distribution of M cells in the canine right and left ventricular free wall near the base of the ventricles. The present study uses standard microelectrode techniques to define their behavior and distribution in the apical region of the ventricular wall as well as in the endocardial structures of the ventricle, including the interventricular septum, papillary muscles, and trabeculae. Action potentials recorded from the M region (deep subepicardium) displayed similar characteristics (steep action potential duration [APD]...Continue Reading

Mentioned in this Paper

Reaction Time
Left Ventricular Structure
Science of Morphology
Action Potentials
Microfold Cell
Integral to Membrane
Perforation of Nasal Septum
Endocardium Specimen

About this Paper

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