Distribution of macrophages in the mouse uterus from one day to three months after parturition, as defined by the immunohistochemical localization of the macrophage-restricted antigens F4/80 and macrosialin

The Anatomical Record
J M Brandon


The morphology of placental detachment sites and the distribution of macrophages were studied in the mouse uterus from day 1 to 3 months post partum. Uterine morphology was studied using H&E and Mallory's Trichrome staining. Macrophages were identified using the macrophage-restricted antigens F4/80 and FA/11 and the leukocyte beta 2-integrin CR3 (Mac-1) which is also expressed by neutrophils. The post-partum wound was infiltrated by large numbers of CR3+ F4/80+ FA/11+ macrophages, and CR3+ neutrophils. The wound resolved rapidly and no inflammatory infiltrate or necrotic tissue was seen by day 5 post partum. The area of the detachment wound and the site of the metrial gland of pregnancy resolved into a structure, here called a post-partum nodule, which persisted for at least three months. The post-partum nodule consisted of an outer layer of collagen around a group of nodule-specific cells which could be divided into haemosiderin- and lipid-bearing phenotypes. The lipid-bearing nodule cells were not found after day 20 post partum. Nodule cells were FA/11+ at all times and also expressed leukocyte common antigen. Expression of CR3 and F4/80 was found on nodule cells up to day 9-10 post partum. CR3 expression was found only occas...Continue Reading


Jan 1, 1992·Current Topics in Microbiology and Immunology·S GordonV H Perry
Jul 1, 1990·Journal of Reproduction and Fertility·J O Nerquaye-Tetteh, J R Clarke
Jan 1, 1990·Journal of Reproduction and Fertility·J M Brandon
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Oct 1, 1982·The Journal of Experimental Medicine·D I BellerR D Schreiber
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon
Jul 1, 1948·Proceedings of the Society for Experimental Biology and Medicine·B L BAKER

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