Distribution of macrophages in the mouse uterus from one day to three months after parturition, as defined by the immunohistochemical localization of the macrophage-restricted antigens F4/80 and macrosialin

The Anatomical Record
J M Brandon

Abstract

The morphology of placental detachment sites and the distribution of macrophages were studied in the mouse uterus from day 1 to 3 months post partum. Uterine morphology was studied using H&E and Mallory's Trichrome staining. Macrophages were identified using the macrophage-restricted antigens F4/80 and FA/11 and the leukocyte beta 2-integrin CR3 (Mac-1) which is also expressed by neutrophils. The post-partum wound was infiltrated by large numbers of CR3+ F4/80+ FA/11+ macrophages, and CR3+ neutrophils. The wound resolved rapidly and no inflammatory infiltrate or necrotic tissue was seen by day 5 post partum. The area of the detachment wound and the site of the metrial gland of pregnancy resolved into a structure, here called a post-partum nodule, which persisted for at least three months. The post-partum nodule consisted of an outer layer of collagen around a group of nodule-specific cells which could be divided into haemosiderin- and lipid-bearing phenotypes. The lipid-bearing nodule cells were not found after day 20 post partum. Nodule cells were FA/11+ at all times and also expressed leukocyte common antigen. Expression of CR3 and F4/80 was found on nodule cells up to day 9-10 post partum. CR3 expression was found only occas...Continue Reading

References

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Jan 1, 1990·Journal of Reproduction and Fertility·J M Brandon
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Citations

Nov 1, 1996·Journal of Reproductive Immunology·J S Hunt, S A Robertson
Oct 17, 2014·Immunological Reviews·Siamon GordonFernando Martinez Estrada
Sep 24, 1999·Biology of Reproduction·A M MacklerS M Yellon
Dec 16, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael R StrugAsgerally T Fazleabas
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L L ReznikovC A Dinarello

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