PMID: 11897804Mar 19, 2002Paper

Distribution of melatonin MT1 receptor immunoreactivity in human retina

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Egemen SavaskanP Meyer

Abstract

Melatonin is synthesized in the pineal gland and retina during the night. Retinal melatonin is believed to be involved in local cellular modulation and in regulation of light-induced entrainment of circadian rhythms. The present study provides the first immunohistochemical evidence for the localization of melatonin 1a-receptor (MT1) in human retina of aged subjects. Ganglion, amacrine, and photoreceptor cells expressed MT1. In addition, MT1 immunoreactivity was localized to cell processes in the inner plexiform layer and to central vessels of the retina, as well as to retinal vessels but not to ciliary or choroidal vessels. These results support a variety of cellular and vascular effects of melatonin in the human retina. Preliminary evidence from patients with Alzheimer's disease (AD) revealed increased MT1 immunoreactivity in ganglion and amacrine cells, as well as in vessels. In AD cases photoreceptor cells were degenerated and showed low MT1 expression.

References

Dec 1, 1989·Experimental Eye Research·A F Wiechmann, J G Hollyfield
Jun 21, 1988·Brain Research·A F WiechmannJ G Hollyfield
Jan 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C ReméF Hafezi
May 8, 1999·Journal of Pineal Research·P L Marchiafava, B Longoni
Jun 18, 1999·Chronobiology International·E D Herzog, G D Block
Oct 7, 2000·Chronobiology International·G Tosini
Dec 13, 2000·Brain Research. Brain Research Reviews·J C de la Torre, G B Stefano
Jul 11, 2001·Neuroscience Letters·E SavaskanF Müller-Spahn

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Citations

Aug 19, 2007·Cell and Tissue Research·Virginie Dinet, Horst-Werner Korf
Aug 9, 2003·Experimental Eye Research·Judite ScherHiroki Fujieda
Jan 25, 2003·Experimental Gerontology·Paola Fontana GasioAnna Wirz-Justice
Feb 3, 2007·Visual Neuroscience·Per O LundmarkDaniel P Cardinali
Dec 25, 2004·Journal of Pineal Research·Egemen SavaskanRalf Jockers
Oct 10, 2013·Science Signaling·Kenkichi BabaGianluca Tosini
Nov 20, 2009·Journal of Circadian Rhythms·Anne-Marie GagnéMarc Hébert
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xin WangRobert M Friedlander
Dec 18, 2013·Progress in Retinal and Eye Research·Douglas G McMahonGianluca Tosini
Oct 22, 2008·The International Journal of Neuroscience·Ester María LópezJuan José López-Costa
Jun 11, 2010·Expert Opinion on Therapeutic Patents·Marco MorGiorgio Tarzia
Oct 22, 2005·The Journal of Physiology·Hai HuangXiong-Li Yang
Sep 11, 2012·Experimental Eye Research·Gianluca TosiniP Michael Iuvone
Sep 19, 2012·Progress in Retinal and Eye Research·Hai HuangXiong-Li Yang
Apr 5, 2008·The Journal of Physiology·Yong PingXiong-Li Yang
Feb 25, 2009·Travel Medicine and Infectious Disease·Gregory M BrownDaniel P Cardinali
Jun 17, 2008·General and Comparative Endocrinology·Sandrine SauzetJack Falcón
Mar 5, 2008·Progress in Retinal and Eye Research·Allan F Wiechmann, Jody A Summers
Jan 19, 2007·Pharmacology & Therapeutics·Pilar Alarma-Estrany, Jesús Pintor
Dec 19, 2006·Experimental Eye Research·Per O LundmarkR E Rosenstein
Jul 5, 2015·Neuroscience·W PackK Y Wong
Oct 10, 2009·British Journal of Pharmacology·F CogéJ A Boutin
May 22, 2008·British Journal of Pharmacology·R JockersP Delagrange
May 25, 2010·Journal of Pineal Research·Ruth E RosensteinDaniel P Cardinali
Jun 7, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gianluca TosiniRalf Jockers
Apr 23, 2005·Progress in Retinal and Eye Research·P Michael IuvoneShyam S Chaurasia
Apr 27, 2005·Survey of Ophthalmology·P D GuptaA R Vasavada
Mar 3, 2015·Journal of Pineal Research·Baptiste LacosteGabriella Gobbi
May 12, 2006·Chronobiology International·Angélique LevoyeJean-Luc Guillaume
Apr 16, 2016·Expert Opinion on Therapeutic Targets·Paul Pévet
Jan 24, 2006·NeuroImage·Tali GorfineNava Zisapel
Mar 23, 2013·International Journal of Molecular Sciences·Annie Po-Yee YimJack Chun-Yiu Cheng
Jul 15, 2017·British Journal of Pharmacology·Erika CeconRalf Jockers
Aug 16, 2019·PloS One·Elena Salobrar-GarcíaJosé M Ramírez

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