PMID: 2097585Oct 30, 1990Paper

Distribution of Met-enkephalyl-Arg-Gly-Leu in rat larynx: partial coexistence with vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y

Neuroscience Letters
J KrekelE Weber

Abstract

Using light microscopic (LM) enzyme-immunohistochemistry on deparaffinized adjacent sections Met-enkephalyl-Arg-Gly-Leu (ME-RGL) immunoreactivity was found to partially coexist with immunoreactive neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine (PHI) in intrinsic laryngeal neurons of the rat. Further ME-RGL-immunoreactive (ir) fibres were found around glands in the subepithelium, in connective tissue of striated muscle and in the perichondrium, as well as around arterial and venous blood vessels. They frequently contacted mast cells and macrophages. The presence of ME-RGL indicates pro-enkephalin-related origin of this novel laryngeal opioid system. From the specific target relations and close interrelations of fibres staining for opioids with those staining for the other peptides--which are known to be more or less characteristic of the sympathetic (NPY), parasympathetic (VIP, PHI) and sensory (calcitonin gene-related peptide; CGRP) subdivisions of the peripheral nervous system--we deduce that opioid/non-opioid interactions might co-control various laryngeal functions, e.g. glandular secretion, blood flow, immune and inflammatory responses and/or might be of relevance in trophic m...Continue Reading

References

Aug 1, 1989·The American Review of Respiratory Disease·T ShimosegawaS I Said
Jul 15, 1987·Experientia·P J Barnes

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Citations

Jan 1, 1995·Cell and Tissue Research·M LidegranS Forsgren
Jun 1, 1993·The Journal of Laryngology and Otology·Y TanakaT Kanaseki
Jul 1, 1991·The International Journal of Neuroscience·E WeiheJ Krekel
Jan 11, 2001·The Annals of Otology, Rhinology & Laryngology. Supplement·Y HisaT Uno

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