Distribution of metabotropic GABA receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus during prenatal and postnatal development

Hippocampus
G López-BenditoRafael Luján

Abstract

Metabotropic gamma-aminobutyric acid receptors (GABAB) play modulatory roles in central synaptic transmission and are involved in controlling neuronal migration during development. We used immunohistochemical methods to elucidate the expression pattern as well as the cellular and the precise subcellular localization of the GABA(B1a/b) and GABAB2 subunits in the rat hippocampus during prenatal and postnatal development. At the light microscopic level, both GABA(B1a/b) and GABAB2 were expressed in the hippocampal primordium from embryonic day E14. During postnatal development, immunoreactivity for GABA(B1a/b) and GABAB2 was distributed mainly in pyramidal cells, with discrete GABA(B1a/b)-immunopositive cell bodies of interneurons present throughout the hippocampus. Using double immunofluorescence, we demonstrated that during the second week of postnatal development, GABA(B1a/b) but not GABAB2 was expressed in glial cells throughout the hippocampal formation. At the electron microscopic level, GABA(B1a/b) and GABAB2 showed a similar distribution pattern during postnatal development. Thus, at all ages the two receptor subunits were located postsynaptically in dendritic spines and shafts at extrasynaptic and perisynaptic sites in bo...Continue Reading

References

Feb 14, 1991·Nature·C H DaviesG L Collingridge
Sep 1, 1994·Neuroscience·S M Turgeon, R L Albin
Sep 1, 1996·Trends in Pharmacological Sciences·G A Johnston
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Mar 20, 1997·Nature·N G Bowery, D A Brown
Aug 4, 1998·Current Opinion in Neurobiology·B BettlerN Bowery
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·K KaupmannB Bettler
Jan 5, 1999·Science·R KunerH C Kornau
Jan 6, 1999·Biochemical and Biophysical Research Communications·S IsomotoK Taniyama
Mar 17, 1999·The Journal of Comparative Neurology·M Margeta-MitrovicA I Basbaum
Aug 24, 1999·The European Journal of Neuroscience·T PfaffA Karschin
Oct 16, 1999·Brain Research. Molecular Brain Research·M M DurkinT A Branchek
Mar 23, 2000·Brain Research·J A ClarkT I Bonner
Jun 21, 2001·Molecular and Cellular Neurosciences·H M ProsserM N Pangalos

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Citations

Aug 26, 2006·Cell and Tissue Research·Hans-Christian Kornau
Jul 11, 2012·Neural Plasticity·Karen KelleyShi-Lung Lin
Aug 15, 2014·Nature Reviews. Neuroscience·Michael J Higley
Jun 2, 2006·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Zhong-wei Zhang
Jun 10, 2009·Frontiers in Neuroendocrinology·Jean Luc Do RegoHubert Vaudry
Dec 20, 2015·Brain Structure & Function·Márton RózsaGábor Tamás
May 26, 2006·The EMBO Journal·Stéphanie M PontierMichel Bouvier
Dec 20, 2008·Journal of Neurochemistry·Carolina LaderaJosé Sánchez-Prieto
Jun 19, 2010·Journal of Neurochemistry·Adrian L OblakGene J Blatt
Nov 22, 2011·The European Journal of Neuroscience·Laura Fernández-AlacidRafael Luján
Apr 29, 2006·Pharmacology & Therapeutics·Bernhard Bettler, Jim Yu-Hsiang Tiao
Aug 6, 2016·Brain Research Bulletin·Laxmi Kumar ParajuliShigeo Okabe
Sep 29, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Werner Kilb
Dec 15, 2016·Frontiers in Neuroanatomy·Carolina AguadoRafael Luján
Sep 8, 2016·Molecular Neurobiology·Mirjam Sibbe, Akos Kulik
Sep 29, 2017·Physiological Reviews·Kenneth A PelkeyChris J McBain
Dec 23, 2011·Journal of Neurophysiology·Masayuki KobayashiNoriaki Koshikawa
Jan 11, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hoda Khoshdel-SarkariziHossein Haghir
Jul 22, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hoda Khoshdel-SarkariziHossein Haghir
Jun 7, 2020·Journal of Molecular Neuroscience : MN·Yogesh Kumar Dhuriya, Divakar Sharma
Aug 1, 2015·The Journal of Physiology·Daniel Bosch, Ingrid Ehrlich
Apr 1, 2011·The Journal of Comparative Neurology·Michaela MetzBernhard Bettler
Mar 7, 2019·Nature Reviews. Neuroscience·Chiayu Q ChiuMichael J Higley
Jan 11, 2020·Frontiers in Neuroanatomy·Sabrina BehuetKatrin Amunts
Jul 7, 2020·Frontiers in Synaptic Neuroscience·George Trompoukis, Costas Papatheodoropoulos
Apr 8, 2020·International Journal of Molecular Sciences·Alejandro Martín-BelmonteRafael Luján
Mar 21, 2020·Neuroscience·Maria V Sanchez-VivesRamon Reig
Feb 13, 2021·Seminars in Cell & Developmental Biology·Joan Jiménez-Balado, Teal S Eich
Aug 24, 2021·Frontiers in Cellular Neuroscience·Charlotte GustorffStefanie Endesfelder

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