Distribution of metabotropic glutamate receptors in the superior colliculus of the adult rat, ferret and cat

Neuroscience
J CironeT E Salt

Abstract

The distribution of different metabotropic glutamate receptors (mGluRs 1a, 1b, 1c, 2/3, 4 and 5) has been compared in the superior colliculus of the rat, cat and ferret using immunohistochemical techniques and light microscopy. We found that although there are differences in labelling patterns between the species, there are also substantial similarities. In general, there was only light staining for the various mGluR1 splice variants, whereas labelling for the other Group I receptor, mGluR5, was heavier and with a pattern which suggested that at least some label arose from retinal afferents to the superficial superior colliculus. A further consistent feature in all species was labelling of astrocytes in the optic nerve/optic tract, superficial superior colliculus and brain at the collicular level with the antibody directed towards the Group II receptors, mGluR2 and mGluR3. Staining for the Group III receptor, mGluR4, was dense in the superficial superior colliculus in all species, with characteristics suggesting nerve fibre staining. mGluR4 staining was seen in the cat optic nerve/optic tract. One source of mGluR4 staining in the superior colliculus may thus be retinal axons, although other sources cannot be entirely excluded. ...Continue Reading

References

May 8, 1995·The Journal of Comparative Neurology·C RomanoJ W Olney
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin

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Citations

Nov 15, 2006·Cerebral Cortex·Christian HennebergerRosemarie Grantyn
Mar 29, 2008·Neuropharmacology·Richard L YoungL Ashley Blackshaw
Oct 11, 2012·The Journal of Comparative Neurology·Marion F HaugStephan C F Neuhauss

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