Distribution of metal-free sulfonated phthalocyanine in subcutaneously transplanted murine tumors

Journal of Photochemistry and Photobiology. B, Biology
Tatyana KarmakovaPaul Vigny

Abstract

Metal-free sulfonated phthalocyanine with the average number of sulfonate groups per molecule 2.4 (H(2)PcS(2.4)) was recently proved to be an efficient photosensitizer for the photodynamic therapy. Fluorescence spectral imaging microscopy was applied here to study localization and relative concentration of H(2)PcS(2.4) with micron-scale resolution in subcutaneously transplanted murine tumors: Ehrlich mammary gland carcinoma (EC), Lewis lung carcinoma (LLC), P388 lymphoid leukemia (P388) and B16 melanoma (B16). The study of cryogenic tissue sections prepared 24 h after H(2)PcS(2.4) intravenous injection revealed that H(2)PcS(2.4) was present in all tissue structures in the monomeric photoactive state. The preferential accumulation of H(2)PcS(2.4) was documented in tumor cells and adjacent non-tumor tissues (skin structures, fatty tissue, connective tissue enriched in fibrous component and infiltrated with fibroblasts and macrophages) for all the studied tumor models. P388 and B16 were stained with H(2)PcS(2.4) less than adjacent skin structures, whereas EC and LLC accumulated H(2)PcS(2.4) alike or higher than particular skin structures. Staining of EC and LLC was similar and ca. 1.4 and 2 times higher than that of B16 and P388, ...Continue Reading

References

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Dec 2, 2000·Journal of Photochemistry and Photobiology. B, Biology·A C Moor
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Citations

Oct 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Renzo Emanuel VeraNatalia Belén Rumie Vittar
Jan 31, 2006·Free Radical Biology & Medicine·George V SharonovAlexei V Feofanov
Jan 31, 2006·Journal of Photochemistry and Photobiology. B, Biology·Itumeleng Seotsanyana-MokhosiTebello Nyokong
Dec 27, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nawal SekkatNorbert Lange
Apr 12, 2007·Diagnostic Cytopathology·Farnaz HastehClaire W Michael
Jun 15, 2006·Analytical Chemistry·Marian NavratilEdgar A Arriaga

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