PMID: 8590023Aug 1, 1995Paper

Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants

Chemical Senses
Mary Beth GenterN J Deamer

Abstract

This study represents part an of ongoing effort to understand the mechanism underlying the distribution of the olfactory mucosal lesion resulting from the systemic administration of compounds such as 2,6-dichlorobenzonitrile (dichlobenil) and beta,beta'-iminodipropionitrile (IDPN). Immunohistochemistry was performed to localize the microsomal form of epoxide hydrolase (mEH) and glutathione S-transferase (GST) isozymes alpha, mu and pi in the rodent olfactory mucosa. GST-pi was found in abundance in the Bowman's glands of the mucosa lining the dorsal medial meatus (DMM) of the nasal cavity and in the nuclei of basal and sustentacular cells of the dorsal and lateral nasal cavity. Liver and olfactory mucosal levels of mEH are equivalent by Western blot analysis. mEH appeared to be localized in the apical cytoplasm of sustentacular cells in all regions of the olfactory mucosa except for the epithelium lining the DMM. These observations, coupled with the known profile of metabolites for dichlobenil, suggest that systemically-administered compounds causing site-specific lesions in the epithelium lining the DMM of the nasal cavity may do so by the in situ production of reactive epoxide metabolites which are then poorly capable of bein...Continue Reading

Citations

Dec 16, 2003·Brain Research·Gwendolyn K Whitby-LoganEric Walters
Dec 21, 2006·Toxicologic Pathology·Alan M JeffreyGary M Williams
Mar 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cuihong JiaColleen C Hegg
Jul 28, 2009·Toxicology·Scott E LovelessRobert C Buck
Mar 26, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Arie Sitthichai MobleyWilliam C Michel
May 12, 2004·Chemico-biological Interactions·Guoyu LingXinxin Ding
Nov 27, 2004·Otolaryngologic Clinics of North America·Urmen D Upadhyay, Eric H Holbrook
Aug 21, 2003·Journal of Neuroscience Research·Michelle WeechEric Walters
Nov 28, 2017·Hormones and Behavior·Spencer G Smith, Katharine V Northcutt

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