Distribution of molecular breast cancer subtypes among Algerian women and correlation with clinical and tumor characteristics: A population-based study

Breast Disease
Farid CherbalHassen Mahfouf

Abstract

Breast cancer is currently the leading cause of cancer morbidity and mortality among Algerian women. Molecular classification of breast cancer is an important factor for prognosis and clinical outcome. There are limited data regarding molecular breast cancer subtypes among Algerian women. The objective of the present study was to analyze the proportion and distribution of molecular subtypes and to determine their associations with some clinical and tumor characteristics: age at diagnosis, menopausal status, histological type and histological grade. The study population included 3014 female breast cancers. We analyzed breast cancers from cancer registries of academic medical oncology service of public hospital of Rouiba, anticancer center of Blida, and anticancer center of Batna. Breast cancers were diagnosed between 2008 and 2013. Molecular subtype classification was done based on immunohistochemical surrogates for ER (Estrogen receptor), PR (Progesterone receptor) and HER2 (human epidermal growth factor receptor-2) status obtained from medical records for 3014 breast cancer patients. Breast cancer subtypes definitions were as follow: Luminal A (ER+ and/or PR+, HER2-), Luminal B (ER+ and/or PR+, HER2+), TNBC (ER-, PR - , HER2-)...Continue Reading

Citations

Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Mohamed A ElkablawyAhmed Alhujaily
Sep 22, 2018·Breast Cancer Research and Treatment·Se Kyung LeeUNKNOWN Korean Breast Cancer Society
Jan 3, 2018·World Journal of Surgical Oncology·Atif Ali HashmiAmir Khan
Nov 25, 2020·BMC Women's Health·Ablavi Adani-IfèTchin Darré
Dec 22, 2020·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Ana Paula Almeida Miranda ReisMateus Rufino Melo
Dec 22, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Achamyelesh GebretsadikDereje G Negera

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